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孕产妇死亡率的时空差异及多尺度行政层级的作用:一项对中国各县为期20年的研究

Spatiotemporal disparities in maternal mortality and the role of multiscale administrative levels: a 20-year study across Chinese counties.

作者信息

Liao Lingfeng, Yuan Fengling, He Yaqian, Xu Shixi, Tang Xingyi, Xie Mingyu, Tang Xianteng, Tang Zhangying, Zeng Guo, Zhang Yumeng, Song Chao

机构信息

HEOA-West China Health & Medical Geography Group, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.

Institute for Healthy Cities and West China Research Centre for Rural Health Development, Sichuan University, Chengdu, Sichuan, China.

出版信息

Front Public Health. 2025 May 9;13:1572382. doi: 10.3389/fpubh.2025.1572382. eCollection 2025.

Abstract

BACKGROUND

China has made progress in reducing maternal mortality ratio (MMR), yet county-level spatiotemporal heterogeneity persists. This study aims to identify spatiotemporal disparities in MMR and quantify the impacts of various administrative levels on these disparities.

METHODS

We analyzed county-level MMR panel data from 1996 to 2015, employing the spatial Gini coefficient, Anselin Local Moran's I, and Getis-Ord Gi to assess spatiotemporal disparities related to spatial inequity and geographic clustering. Additionally, we applied a Bayesian multiscale spatiotemporally varying intercepts (BMSTVI) model to unveil the national temporal trend and multiple sub-national spatial patterns in maternal mortality risk. We further quantified the relative contributions of five sub-national administrative levels using the spatiotemporal variance partitioning index (STVPI).

RESULTS

Results suggested that from 1996 to 2015, the proportion of MMR in counties achieving Sustainable Development Goals (SDGs) increased from 27.05% to 93.40%, yet spatiotemporal disparities remained. The spatial Gini coefficient and geographic clustering analyses indicated temporally varying but spatially stable inequities patterns, highlighting the Spatial Inequity Lock-in (SILI) effect. Hotspot analysis identified sensitive and exemplary counties, underscoring the need for targeted regional interventions. The BMSTVI model indicated a declining trend in MMR risk over 20 years, with the most substantial reduction from 2003 to 2012. While the geographic distribution of high-risk areas remained relatively stable, analyses at finer administrative levels enabled more precise identification of affected locations and improved intervention effectiveness. Finally, the STVPI revealed that spatial effects contributed 83.91% (95% CIs: 78.66%-89.47%) to MMR variations, far exceeding the 11.60% (95% CIs: 7.27%-16.55%) from temporal effects. The contribution from the administrative county-level was the highest (29.15%, 95% CIs: 19.69%-35.06%), followed by contributions from the seven geographical regions (14.10%, 95% CIs: 6.61%-34.06%), rural-urban differences (13.77%, 95% CIs: 4.93%-39.2%), provincial level (12.41%, 95% CIs: 8.06%-16.85%), and city level (11.21%, 95% CIs: 7.53%-13.84%).

DISCUSSION

These findings underscore the crucial need for region-specific, time-sensitive policies to achieve maternal health equity across Chinese counties. This study provides a robust empirical foundation for a multi-tiered adaptive policy framework grounded in systematic spatiotemporal assessment across macro, meso, and micro scales to guide targeted maternal health interventions globally.

摘要

背景

中国在降低孕产妇死亡率(MMR)方面取得了进展,但县级时空异质性仍然存在。本研究旨在确定MMR的时空差异,并量化各级行政层面因素对这些差异的影响。

方法

我们分析了1996年至2015年的县级MMR面板数据,采用空间基尼系数、安塞尔林局部莫兰指数(Anselin Local Moran's I)和Getis-Ord Gi指数来评估与空间不平等和地理聚集相关的时空差异。此外,我们应用贝叶斯多尺度时空变化截距(BMSTVI)模型来揭示全国孕产妇死亡风险的时间趋势和多个国家以下层面的空间模式。我们进一步使用时空方差分解指数(STVPI)量化五个国家以下行政层面因素的相对贡献。

结果

结果表明,1996年至2015年期间,实现可持续发展目标(SDG)的县的MMR比例从27.05%上升至93.40%,但时空差异依然存在。空间基尼系数和地理聚集分析表明,不平等模式随时间变化但在空间上保持稳定,凸显了空间不平等锁定(SILI)效应。热点分析确定了敏感县和典型县,强调了有针对性的区域干预的必要性。BMSTVI模型表明,MMR风险在20年里呈下降趋势,2003年至2012年期间下降幅度最大。虽然高风险地区的地理分布保持相对稳定,但在更精细行政层面的分析能够更精确地识别受影响地区,并提高干预效果。最后,STVPI显示,空间因素对MMR变化的贡献为83.91%(95%可信区间:78.66%-89.47%),远远超过时间因素的11.60%(95%可信区间:7.27%-16.55%)。县级行政层面因素的贡献最高(29.15%,95%可信区间:19.69%-35.06%),其次是七个地理区域的贡献(14.10%,95%可信区间:6.61%-34.06%)、城乡差异(13.77%,95%可信区间:4.93%-39.2%)、省级层面(12.41%,95%可信区间:8.06%-16.85%)和市级层面(11.21%,95%可信区间:7.53%-13.84%)。

讨论

这些发现强调了制定针对特定地区、对时间敏感的政策对于在中国各县实现孕产妇健康公平的迫切需求。本研究为一个多层适应性政策框架提供了有力的实证基础,该框架基于对宏观、中观和微观尺度的系统时空评估,以指导全球范围内有针对性的孕产妇健康干预措施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e58/12100663/933b2941ab14/fpubh-13-1572382-g0001.jpg

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