Gallala Mahdi
Animal Resources Department, Ministry of Municipality, Doha, State of Qatar.
Open Life Sci. 2025 May 20;20(1):20251095. doi: 10.1515/biol-2025-1095. eCollection 2025.
The poultry industry faces multifaceted challenges, including escalating demand for poultry products, climate change impacting feed availability, emergence of novel avian pathogens, and antimicrobial resistance. Traditional disease control measures are costly and not always effective, prompting the need for complementary methods. Gene editing (GE, also called genome editing) technologies, particularly CRISPR/Cas9, offer promising solutions. This article summarizes recent advancements in utilizing CRISPR/Cas GE to enhance infectious disease control in poultry. It begins with an overview of modern GE techniques, highlighting CRISPR/Cas9's advantages over other methods. The potential applications of CRISPR/Cas in poultry infectious disease prevention and control are explored, including the engineering of innovative vaccines, the generation of disease-resilient birds, and pathogen targeting. Additionally, insights are provided regarding regulatory frameworks and future perspectives in this rapidly evolving field.
家禽业面临多方面挑战，包括对家禽产品的需求不断增加、气候变化影响饲料供应、新型禽类病原体的出现以及抗菌药物耐药性。传统的疾病控制措施成本高昂且并非总是有效，因此需要补充方法。基因编辑（GE，也称为基因组编辑）技术，尤其是CRISPR/Cas9，提供了有前景的解决方案。本文总结了利用CRISPR/Cas基因编辑技术加强家禽传染病控制的最新进展。文章首先概述了现代基因编辑技术，强调了CRISPR/Cas9相对于其他方法的优势。探讨了CRISPR/Cas在家禽传染病预防和控制中的潜在应用，包括创新疫苗的研发、培育抗病禽类以及靶向病原体。此外，还提供了有关这一快速发展领域的监管框架和未来展望的见解。
