Mishu Mahbuba Akther, Nath Sabuj Kanti, Sohidullah M, Hossain Md Taslim
Department of Agricultural Finance, Co-operatives and Banking, Khulna Agricultural University, Khulna, Bangladesh.
Department of Animal Nutrition, Khulna Agricultural University, Khulna, Bangladesh.
J Adv Vet Anim Res. 2024 Jun 21;11(2):483-493. doi: 10.5455/javar.2024.k798. eCollection 2024 Jun.
CRISPR-associated proteins and clustered regularly interspaced short palindromic repeats (CRISPR-Cas) technology has emerged as a groundbreaking advancement in animal and poultry nutrition to improve feed conversion efficiency, enhance disease resistance, and improve the nutritional quality of animal products. Despite significant advancements, there is a research gap in the systematic understanding and comprehensive use of the CRISPR-Cas method in animal and poultry nutrition. The purpose of this study is to elucidate the latest advancements in animal and poultry nutrition through CRISPR-Cas genome editing technology, focusing on gene manipulation in metabolism, immunity, and growth. Following preferred reporting items in meta-analysis and systematic reviews guidelines, we conducted a systematic search using several databases, including Scopus, PubMed, and Web of Science, until May 2024, and finally, we included a total of 108 articles in this study. This article explores the use of the CRISPR-Cas system in the advancement of feed additives like probiotics and enzymes, which could reduce the use of antibiotics in animal production. Furthermore, the article discusses ethical and regulatory issues related to gene editing in animal and poultry nutrition, including concerns about animal welfare, food safety, and environmental impacts. Overall, the CRISPR-Cas system holds substantial promise to overcome the challenges in modern animal agriculture. By enriching the nutritional quality of animal products, increasing disease resistance, and improving feed efficiency, it offers sustainable and cost-effective solutions that can revolutionize animal and poultry nutrition.
成簇规律间隔短回文重复序列（CRISPR）相关蛋白和CRISPR - Cas技术已成为畜禽营养领域的一项突破性进展，可提高饲料转化效率、增强抗病能力并改善动物产品的营养品质。尽管取得了重大进展，但在畜禽营养领域对CRISPR - Cas方法的系统理解和全面应用方面仍存在研究空白。本研究的目的是通过CRISPR - Cas基因组编辑技术阐明畜禽营养领域的最新进展，重点关注代谢、免疫和生长方面的基因操作。按照荟萃分析和系统评价指南中的首选报告项目，我们使用了包括Scopus、PubMed和Web of Science在内的多个数据库进行系统检索，直至2024年5月，最终本研究共纳入108篇文章。本文探讨了CRISPR - Cas系统在推进益生菌和酶等饲料添加剂方面的应用，这可能会减少动物生产中抗生素的使用。此外，本文还讨论了畜禽营养领域基因编辑相关的伦理和监管问题，包括对动物福利、食品安全和环境影响的担忧。总体而言，CRISPR - Cas系统在克服现代畜牧业挑战方面具有巨大潜力。通过提高动物产品的营养品质、增强抗病能力和提高饲料效率，它提供了可持续且具有成本效益的解决方案，可能会彻底改变畜禽营养领域。
