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具有广泛横纹肌样分化的子宫肿瘤,类似卵巢性索肿瘤:一例报告。

Uterine tumor resembling ovarian sex cord tumor with extensive rhabdoid differentiation: A case report.

作者信息

Yang Rumeng, Liu Liwei

机构信息

Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, Hubei, China.

出版信息

Open Life Sci. 2025 May 20;20(1):20251104. doi: 10.1515/biol-2025-1104. eCollection 2025.

DOI:10.1515/biol-2025-1104
PMID:40417005
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12103180/
Abstract

Uterine tumor resembling ovarian sex cord tumor (UTROSCT) is a rare uterine mesenchymal tumor, which is classified as a tumor with uncertain malignant potential. In this case report, we reported a 52-year-old woman who was diagnosed with UTROSCT through pathological examination of uterine intramural nodules. We reported the diagnosis and treatment process, aiming to provide new evidence and insights for the diagnosis and treatment of this rare disease.

摘要

子宫性索样肿瘤(UTROSCT)是一种罕见的子宫间叶肿瘤,被归类为恶性潜能不确定的肿瘤。在本病例报告中,我们报道了一名52岁女性,通过子宫肌壁间结节的病理检查被诊断为UTROSCT。我们报告了诊断和治疗过程,旨在为这种罕见疾病的诊断和治疗提供新的证据和见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1391/12103180/837dbf058d71/j_biol-2025-1104-fig002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1391/12103180/345eadd5c146/j_biol-2025-1104-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1391/12103180/837dbf058d71/j_biol-2025-1104-fig002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1391/12103180/345eadd5c146/j_biol-2025-1104-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1391/12103180/837dbf058d71/j_biol-2025-1104-fig002.jpg

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Uterine tumor resembling ovarian sex cord tumor with extensive rhabdoid differentiation: A case report.具有广泛横纹肌样分化的子宫肿瘤,类似卵巢性索肿瘤:一例报告。
Open Life Sci. 2025 May 20;20(1):20251104. doi: 10.1515/biol-2025-1104. eCollection 2025.
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Hum Pathol. 2024 Jan;143:33-41. doi: 10.1016/j.humpath.2023.11.007. Epub 2023 Nov 23.
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4
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本文引用的文献

1
Uterine Tumor Resembling Ovarian Sex Cord Tumor: Clinicopathological Characteristics of a Rare Case.子宫肿瘤酷似卵巢性索肿瘤:1例罕见病例的临床病理特征
Case Rep Oncol. 2020 Jul 8;13(2):807-812. doi: 10.1159/000508180. eCollection 2020 May-Aug.
2
Uterine Tumor Resembling Ovarian Sex Cord Stromal Tumor (UTROSCT): A Series of 3 Cases With Extensive Rhabdoid Differentiation, Malignant Behavior, and ESR1-NCOA2 Fusions.子宫肿瘤类似于卵巢性索间质肿瘤(UTROSCT):3 例广泛横纹肌样分化、恶性行为和 ESR1-NCOA2 融合的病例系列。
Am J Surg Pathol. 2020 Nov;44(11):1563-1572. doi: 10.1097/PAS.0000000000001543.
3
Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT): A Morphologic and Molecular Study of 26 Cases Confirms Recurrent NCOA1-3 Rearrangement.
子宫肿瘤类似于卵巢性索间质肿瘤(UTROSCT):26 例形态学和分子研究证实了 NCOA1-3 重排的复发。
Am J Surg Pathol. 2020 Jan;44(1):30-42. doi: 10.1097/PAS.0000000000001348.
4
Uterine tumor resembling ovarian sex cord tumor: a clinicopathological and immunohistochemical analysis of two cases and a literature review.子宫肿瘤酷似卵巢性索肿瘤:两例临床病理及免疫组化分析并文献复习
J Int Med Res. 2019 Mar;47(3):1339-1347. doi: 10.1177/0300060518821824. Epub 2019 Feb 8.
5
Uterine Tumor Resembling Ovarian Sex Cord Tumor: A Distinct Entity Characterized by Recurrent NCOA2/3 Gene Fusions.具有 NCOA2/3 基因融合的复发性特征的类似于卵巢性索肿瘤的子宫肿瘤:一个独特的实体。
Am J Surg Pathol. 2019 Feb;43(2):178-186. doi: 10.1097/PAS.0000000000001153.
6
Uterine tumour resembling ovarian sex cord tumour: first report of a large series with follow-up.类似于卵巢性索肿瘤的子宫肿瘤:大型系列病例报道及随访。
Histopathology. 2017 Nov;71(5):751-759. doi: 10.1111/his.13296. Epub 2017 Sep 8.
7
SF1 immunohistochemistry is useful in differentiating uterine tumours resembling sex cord-stromal tumours from potential histological mimics.SF1免疫组化有助于将类似性索间质肿瘤的子宫肿瘤与潜在的组织学模仿物区分开来。
Pathology. 2016 Aug;48(5):434-40. doi: 10.1016/j.pathol.2016.03.013. Epub 2016 Jun 14.
8
Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT) Commonly Exhibits Positivity With Sex Cord Markers FOXL2 and SF-1 but Lacks FOXL2 and DICER1 Mutations.子宫肿瘤样卵巢性索肿瘤(UTROSCT)通常对性索标记物FOXL2和SF-1呈阳性反应,但缺乏FOXL2和DICER1突变。
Int J Gynecol Pathol. 2016 Jul;35(4):301-8. doi: 10.1097/PGP.0000000000000240.
9
Uterine tumors resembling ovarian sex cord tumors.类似于卵巢性索肿瘤的子宫肿瘤。
Arch Pathol Lab Med. 2013 Dec;137(12):1832-6. doi: 10.5858/arpa.2012-0634-RS.
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Uterine tumors resembling ovarian sex cord tumors (UTROSCT) lack the JAZF1-JJAZ1 translocation frequently seen in endometrial stromal tumors.子宫性索样肿瘤(UTROSCT)缺乏在子宫内膜间质瘤中常见的JAZF1-JJAZ1易位。
Am J Surg Pathol. 2009 Aug;33(8):1206-12. doi: 10.1097/PAS.0b013e3181a7b9cf.