Patel Mrudula
Department of Clinical Microbiology and Infectious Diseases, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2050, South Africa.
Pathogens. 2022 Mar 10;11(3):335. doi: 10.3390/pathogens11030335.
colonisation of the oral cavity increases in immunocompromised individuals which leads to the development of oral candidiasis. In addition, host factors such as xerostomia, smoking, oral prostheses, dental caries, diabetes and cancer treatment accelerate the disease process. is the primary causative agent of this infection, owing to its ability to form biofilm and hyphae and to produce hydrolytic enzymes and candialysin. Although mucosal immunity is activated, from the time hyphae-associated toxin is formed by the colonising cells, an increased number and virulence of this pathogenic organism collectively leads to infection. Prevention of the development of infection can be achieved by addressing the host physiological factors and habits. For maintenance of oral health, conventional oral hygiene products containing antimicrobial compounds, essential oils and phytochemicals can be considered, these products can maintain the low number of in the oral cavity and reduce their virulence. Vulnerable patients should be educated in order to increase compliance.
免疫功能低下个体的口腔定植增加，这会导致口腔念珠菌病的发展。此外，诸如口干症、吸烟、口腔修复体、龋齿、糖尿病和癌症治疗等宿主因素会加速疾病进程。 是这种感染的主要病原体，因为它能够形成生物膜和菌丝，并产生水解酶和念珠菌溶素。尽管黏膜免疫被激活，但从定植的 细胞形成菌丝相关毒素之时起，这种致病生物体数量的增加及其毒力共同导致感染。通过解决宿主生理因素和习惯可以预防感染的发生。为保持口腔健康，可以考虑使用含有抗菌化合物、精油和植物化学物质的传统口腔卫生产品，这些产品可以维持口腔中较低的 数量并降低其毒力。应对易感染患者进行教育，以提高依从性。
