Coxon J E, Dickson C, Taylor I
Br J Surg. 1985 Sep;72(9):690-3. doi: 10.1002/bjs.1800720906.
The effect of chronic progressive distal large bowel obstruction on colonic motility was studied in six mini-pigs. Motility was detected in vivo during the development of obstruction with chronically implanted Ag/AgCl electrodes using an impedance technique. When the obstruction was complete the segments of bowel were resected and spontaneous contractile activity and response to cholinergic stimulation were studied in an organ bath. Any hypermotility resulting from obstruction was shortlived and a gradual state of hypomotility supervened proximal to the obstruction. Decompression of the bowel did not result in the immediate return of motility and the resected bowel was unresponsive to carbachol. These results suggest that spontaneous resolution of large bowel obstruction is unlikely and that motility disturbances are unlikely to be a cause of anastomotic dehiscence.
在六只小型猪中研究了慢性进行性远端大肠梗阻对结肠动力的影响。在梗阻发展过程中，使用阻抗技术通过长期植入的银/氯化银电极在体内检测动力。当梗阻完全形成时，切除肠段，并在器官浴中研究其自发收缩活动和对胆碱能刺激的反应。梗阻导致的任何运动亢进都是短暂的，梗阻近端逐渐出现运动减弱状态。肠道减压并未导致动力立即恢复，切除的肠道对卡巴胆碱无反应。这些结果表明，大肠梗阻不太可能自行缓解，且动力障碍不太可能是吻合口裂开的原因。
