Orsolini Morgan, Russack Jason, Huynh Huey, Raburn Douglas, Fox John, Schust Danny
Duke University, Department of Obstetrics and Gynecology, Durham, NC USA.
LifeAire Systems, Allentown, PA USA.
F S Rev. 2025 Jun;6(1). doi: 10.1016/j.xfnr.2025.100090. Epub 2025 Mar 27.
IVF as a clinical method to surmount infertility has existed since the 1970s, and yet fertilization, embryo development, pregnancy, and live birth rates remain unacceptably low. Although a multitude of factors may contribute to stagnated success despite substantial advances in basic and applied IVF sciences, gamete quality is inarguably integral to IVF success rates. In this review, the authors will explore the role of environmental toxicology in impairing fertility and gamete quality prior to starting IVF that will influence downstream IVF success. contaminants of interest that may affect gamete potential in the context of IVF include heavy metals, per- and polyfluoroalkyl substances (PFAS), persistent organic pollutants (POPs), and airborne contaminants. By evaluating the current literature on reproductive toxicology and how toxic exposures may influence IVF, this review aims to provide a comprehensive reference of potential toxicological exposures for clinicians, to use and animal data to supplement correlative human studies with potential causative mechanisms, and to strengthen the case for patient assessment of toxicological risk.
自20世纪70年代以来，体外受精（IVF）作为一种克服不孕症的临床方法就已存在，但受精、胚胎发育、妊娠和活产率仍然低得令人难以接受。尽管基础和应用IVF科学取得了重大进展，但仍有许多因素可能导致成功率停滞不前，不过配子质量无疑是IVF成功率的一个重要组成部分。在这篇综述中，作者将探讨环境毒理学在IVF开始前对生育能力和配子质量的损害作用，这将影响IVF的下游成功率。在IVF背景下可能影响配子潜能的相关污染物包括重金属、全氟和多氟烷基物质（PFAS）、持久性有机污染物（POPs）以及空气传播污染物。通过评估当前关于生殖毒理学的文献以及毒性暴露如何影响IVF，本综述旨在为临床医生提供潜在毒理学暴露的全面参考资料，利用动物数据补充具有潜在致病机制的相关人体研究，并加强对患者进行毒理学风险评估的理由。
