Sokan-Adeaga Adewale Allen, Sokan-Adeaga Micheal Ayodeji, Sokan-Adeaga Eniola Deborah, Oparaji Anastasia Nkem, Edris Hoseinzadeh, Tella Esther Oluwabukunola, Balogun Francis Adeniyi, Aledeh Muhammad, Amubieya Oluwatosin Emmanuel
Department of Environmental Health Science, Faculty of Public Health, College of Medicine, Lead City University, Ibadan, Nigeria.
Department of Community Health and Primary Health Care, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Lagos, Nigeria.
J Public Health Res. 2023 Jun 29;12(2):22799036231181226. doi: 10.1177/22799036231181226. eCollection 2023 Apr.
Toxicity arising from environmental contaminants has attracted global interest in the last few decades, due to the high morbidity and mortality associated with them. Efforts have been made to combat the consequential outcomes of environmental toxicity in humans through traditional remediation techniques and therapeutic measures which have been hampered by one or more limitations. Consequently, this scenario has triggered interest in the medicinal properties of phytochemicals. Thus, this review gives a succinct and in-depth elucidation of the various environmental contaminants and their toxicity effects on humans. It delves into the various classes of phytochemicals and their intervention roles. The study adopted a desk review of existing literatures from scientific reports and peer reviewed articles through triangulation of data sources. "Phytochemicals" are group of secondary metabolites obtained from plants with medicinal properties. These groups of compounds are included but not limited to flavonoids, tannins, saponins, alkaloids, cardenoloids, terpenoids, and phytosteroids. This review corroborates the prophylactic and therapeutics efficacy of these phytochemicals as anti-metastatic, anti-inflammatory, anti-aging, anti-oxidant, anti-microbial and live saving substances with empirical findings from several laboratory, clinical trials and epidemiologic studies. It conclude that given the wide range of medicinal properties of phytochemicals, there is an urgent need for its full optimization in the pharmaceutical industry and future studies should focus on identifying the bioactive molecules in these compounds and its effectiveness against mixer toxicity.
在过去几十年中，环境污染物产生的毒性因其引发的高发病率和死亡率而引起了全球关注。人们已努力通过传统修复技术和治疗措施来对抗环境毒性对人类造成的后果，但这些措施受到了一个或多个限制的阻碍。因此，这种情况引发了人们对植物化学物质药用特性的兴趣。因此，本综述对各种环境污染物及其对人类的毒性影响进行了简洁而深入的阐述。它深入探讨了各类植物化学物质及其干预作用。该研究通过对数据来源进行三角测量，对科学报告和同行评审文章中的现有文献进行了案头审查。“植物化学物质”是从具有药用特性的植物中获得的次生代谢产物组。这些化合物组包括但不限于黄酮类化合物、单宁、皂苷、生物碱、强心苷、萜类化合物和植物甾醇。本综述通过多项实验室、临床试验和流行病学研究的实证结果，证实了这些植物化学物质作为抗转移、抗炎、抗衰老、抗氧化、抗菌和救命物质的预防和治疗功效。研究得出结论，鉴于植物化学物质具有广泛的药用特性，迫切需要在制药行业对其进行全面优化，未来的研究应侧重于确定这些化合物中的生物活性分子及其对混合毒性的有效性。
