Walsh David P
University of Missouri - Kansas City, Kansas City, MO.
AMIA Annu Symp Proc. 2025 May 22;2024:1169-1175. eCollection 2024.
Hidradenitis suppurativa is an autoinflammatory condition resulting in painful cysts, nodules, and sinus tracts in areas of high skin on skin contact. The microenvironment of affected tissues is high in pro-inflammatory cytokines and T-helper 17 cells. Other auto-inflammatory diseases, like psoriasis, have an enhanced risk of systemic inflammation and an elevated risk of spontaneous abortion. A cohort of pregnant patients from Cerner Health Facts® was identified using a Python adaptation of a validated pregnancy identification and classification algorithm. The HS population was identified among the pregnant population and was shown to be statistically significantly associated with outcome type by Chi square. A multinomial logistic regression also indicated a statistically significant increase in the odds of a pregnant patient having a spontaneous abortion over a live birth when controlling for thyroid disease, polycystic ovarian syndrome, antiphospholipid syndrome, other inflammatory diseases, and advanced maternal age.
化脓性汗腺炎是一种自身炎症性疾病，会在皮肤接触频繁的部位形成疼痛性囊肿、结节和窦道。受影响组织的微环境中促炎细胞因子和辅助性T细胞17含量较高。其他自身炎症性疾病，如银屑病，发生全身性炎症的风险增加，自然流产的风险也升高。使用经过验证的妊娠识别和分类算法的Python改编版，从Cerner Health Facts®中识别出一组孕妇。在孕妇群体中识别出化脓性汗腺炎患者，并通过卡方检验显示其与结局类型存在统计学显著关联。多项逻辑回归还表明，在控制甲状腺疾病、多囊卵巢综合征、抗磷脂综合征、其他炎症性疾病和高龄产妇等因素后，孕妇自然流产的几率相较于活产有统计学显著增加。
