Dong Chunlin, Ma Ding, Gu Ke, Lin Yaying, Song Jing, Wang Yuan, Yu Jinjin, Zhou Yanjun
Department of Obstetrics and Gynecology, Affiliated Hospital of Jiangnan University, Wuxi, People's Republic of China.
Wuxi Medical College, Jiangnan University, Wuxi, People's Republic of China.
Int J Womens Health. 2025 May 19;17:1421-1436. doi: 10.2147/IJWH.S514304. eCollection 2025.
The menopausal transition is accompanied by metabolic changes in women. This study explores the Chinese visceral adiposity index (CVAI) as a potential indicator of menopausal status to aid in disease prevention.
A cohort of 404 premenopausal Chinese women aged 45 years and above, from the China Health and Retirement Longitudinal Study (CHARLS), was included. CVAI was calculated from the 2011 survey data, menopausal status was collected in the 2018 survey, representing a 7-year longitudinal follow-up. The cross-sectional study cohort from the National Health and Nutrition Examination Survey (NHANES) included 3577 women aged 40-60 with CVAI and self-reported menopausal status from 2003 to 2020. Logistic regression models were estimated the odds ratio (OR) of the menopause data and 95% confidence intervals (CIs).
In the CHARLS cohort, the adjusted OR for menopause in the fourth quartile of CVAI compared to the first quartile was 5.23 (95% CI: 1.59, 17.17; P for trend: 0.005). Additionally, a significant difference in the association between menopausal status and CVAI was found between rural and urban populations (P for interaction = 0.029). Moreover, in the NHANES cohort, the CVAI and the menopausal status were associated after adjustment (OR: 1.02, 95% CI: 1.002, 1.037, P: 0.029). In the stratified analysis, the association of CVAI with the status of menopause was observed among other ethnicities which including Asians (OR: 1.092, 95% CI: 1.012, 1.178, P: 0.025). Finally, a nomogram was developed to facilitate the clinical assessment of menopause based on the CVAI.
The CVAI demonstrated a significant association with the odds of menopausal status in both Chinese and the US populations, suggesting its potential as a correlative marker for menopausal status, but the associational strength may vary by population.
女性绝经过渡伴随着代谢变化。本研究探索中国内脏脂肪指数（CVAI）作为绝经状态的潜在指标，以助力疾病预防。
纳入了来自中国健康与养老追踪调查（CHARLS）的404名45岁及以上的绝经前中国女性。CVAI根据2011年调查数据计算得出，绝经状态在2018年调查中收集，代表7年的纵向随访。来自美国国家健康与营养检查调查（NHANES）的横断面研究队列包括3577名40 - 60岁的女性，她们有CVAI数据以及2003年至2020年的自我报告绝经状态。采用逻辑回归模型估计绝经数据的比值比（OR）和95%置信区间（CIs）。
在CHARLS队列中，与第一四分位数相比，CVAI第四四分位数的绝经调整后OR为5.23（95% CI：1.59，17.17；趋势P值：0.005）。此外，农村和城市人群在绝经状态与CVAI之间的关联存在显著差异（交互作用P值 = 0.029）。而且，在NHANES队列中，调整后CVAI与绝经状态相关（OR：1.02，95% CI：1.002，1.037，P值：0.029）。在分层分析中，在包括亚洲人在内的其他种族中观察到CVAI与绝经状态的关联（OR：1.092，95% CI：1.012，1.178，P值：0.025）。最后，开发了一种列线图以基于CVAI促进绝经的临床评估。
CVAI在中国和美国人群中均显示出与绝经状态的几率存在显著关联，表明其作为绝经状态相关标志物的潜力，但关联强度可能因人群而异。
