Sindahl Per, Møllebæk Mathias, Gardarsdottir Helga, De Bruin Marie Louise, Hallgreen Christine Erikstrup, Clemmensen Marianne Hald
Division of Pharmacovigilance and Medical Devices, Danish Medicines Agency, Axel Heides Gade 1, Copenhagen 2300, Denmark.
Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
Ther Adv Drug Saf. 2025 May 24;16:20420986251333911. doi: 10.1177/20420986251333911. eCollection 2025.
The efficient distribution of Direct Healthcare Professional Communications (DHPCs) is crucial for ensuring healthcare providers promptly receive important new safety information.
This study aimed to evaluate the implementation of the electronic distribution of DHPCs by the Danish Medicines Agency (DKMA) and to assess how future safety communication can be improved.
We conducted a web-based cross-sectional survey among Danish physicians using a self-administered questionnaire.
DKMA sends DHPCs to healthcare professionals via an electronic mailbox called e-Boks which is linked to the unique personal identifier. To evaluate DKMA's distribution of DHPCs, participants were asked about awareness, frequency and barriers of reading, preferred distribution channel and overall satisfaction. To further identify potential improvements, respondents were asked about general preferences regarding sender and channels of safety information in addition to which information sources they use to keep up-to-date.
A total of 2238 physicians completed the survey corresponding to a response rate of 26% based on the total target population. The total awareness was 81%. Compared to previous research, awareness of GPs increased from 66% to 82%, and the percentage of GPs who rarely or never read DHPCs decreased from 33% to 20%. In addition, our study revealed a preference for receiving DHPCs electronically through e-Boks as opposed to workplace-delivered postal letters, and a preference for the DKMA over pharmaceutical companies as the sender of DHPCs. One-third of the respondents were either 'dissatisfied' or 'very dissatisfied' with the current solution. A professional mailbox and point-of-care alerts when prescribing may complement the primary distribution channel to strengthen the uptake. Additionally, existing information sources already frequented by the target group may be used to communicate safety information.
The DKMA's electronic distribution of DHPCs suggests an improvement and may serve as inspiration for other agencies. However, the considerable dissatisfaction calls for further improvements.
直接医疗专业人员沟通(DHPCs)的有效分发对于确保医疗服务提供者及时收到重要的新安全信息至关重要。
本研究旨在评估丹麦药品管理局(DKMA)实施DHPCs电子分发的情况,并评估如何改进未来的安全沟通。
我们使用自填式问卷对丹麦医生进行了基于网络的横断面调查。
DKMA通过一个名为e-Boks的电子邮箱向医疗专业人员发送DHPCs,该邮箱与唯一的个人标识符相关联。为了评估DKMA对DHPCs的分发情况,参与者被问及对阅读的知晓度、频率和障碍、偏好的分发渠道以及总体满意度。为了进一步确定潜在的改进措施,除了询问他们用于了解最新信息的信息来源外,还询问了受访者对安全信息发送者和渠道的一般偏好。
共有2238名医生完成了调查,根据总目标人群计算,回复率为26%。总知晓率为81%。与之前的研究相比,全科医生的知晓率从66%提高到了82%,很少或从不阅读DHPCs的全科医生比例从33%下降到了20%。此外,我们的研究表明,与通过工作场所投递的邮政信件相比,更倾向于通过e-Boks以电子方式接收DHPCs,并且更倾向于DKMA而不是制药公司作为DHPCs的发送者。三分之一的受访者对当前的解决方案“不满意”或“非常不满意”。专业邮箱和开处方时的即时护理提醒可能会补充主要分发渠道,以加强信息的获取。此外,可以利用目标群体已经经常使用的现有信息来源来传达安全信息。
DKMA对DHPCs的电子分发显示出了改进,可能为其他机构提供借鉴。然而,相当多的不满表明需要进一步改进。