Zhou Xiaoling, Xiao Li, Lai Fan, Chen Wei, Zhou Congrong, Deng Yi, Wang Tao, Xing Shasha, Diao Haoyang, Tang Mi, Guo Wenmei, Luo Erdan
Department of Pharmacy, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Department of Medical Affairs, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Front Med (Lausanne). 2025 May 9;12:1521587. doi: 10.3389/fmed.2025.1521587. eCollection 2025.
Antibodies have been widely used globally over the past decade and play an increasingly important role in modern medicine. Notably, significant advancements have been achieved in the realm of gynecology, particularly in gynecological cancers. This study endeavors to present a thorough overview of antibody-related drug clinical studies in gynecology registered on ClinicalTrials.gov, focusing on the basic characteristics of trials, geographical distribution, administration routes, indications, and targets. The analysis indicates a rising prevalence of antibody-drug conjugates (ADCs), bispecific antibodies, and Fc-fusion proteins. This study will help develop new ideas for future research on antibodies in gynecology.
在过去十年中,抗体在全球范围内得到了广泛应用,并在现代医学中发挥着越来越重要的作用。值得注意的是,在妇科领域,尤其是妇科癌症方面取得了重大进展。本研究旨在全面概述在ClinicalTrials.gov上注册的妇科抗体相关药物临床研究,重点关注试验的基本特征、地理分布、给药途径、适应症和靶点。分析表明,抗体药物偶联物(ADC)、双特异性抗体和Fc融合蛋白的应用越来越普遍。本研究将有助于为未来妇科抗体研究开拓新思路。