Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA; Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA; Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Biochim Biophys Acta Rev Cancer. 2024 Mar;1879(2):189079. doi: 10.1016/j.bbcan.2024.189079. Epub 2024 Jan 26.
Angiogenesis is a crucial process for tissue development, repair, and tumor survival. Vascular endothelial growth factor (VEGF) is a key driver secreted by cancer cells, promoting neovascularization. While VEGF's role in angiogenesis is well-documented, its influence on the other aspects in tumor microenvironemt is less discussed. This review elaborates on VEGF's impact on intercellular interactions within the tumor microenvironment, including how VEGF affects pericyte proliferation and migration and mediates interactions between tumor-associated macrophages and cancer cells, resulting in PDL-1-mediated immunosuppression and Nrf2-mediated epithelial-mesenchymal transition. The review discusses VEGF's involvement in intra-organelle crosstalk, tumor metabolism, stemness, and epithelial-mesenchymal transition. It also provides insights into current anti-VEGF therapies and their limitations in cancer treatment. Overall, this review aims to provide a thorough overview of the current state of knowledge concerning VEGF signaling and its impact, not only on angiogenesis but also on various other oncogenic processes.
血管生成是组织发育、修复和肿瘤存活的关键过程。血管内皮生长因子（VEGF）是癌细胞分泌的关键驱动因子，促进新血管生成。虽然 VEGF 在血管生成中的作用已有充分的记录，但它对肿瘤微环境中其他方面的影响讨论较少。这篇综述详细阐述了 VEGF 对肿瘤微环境中细胞间相互作用的影响，包括 VEGF 如何影响周细胞的增殖和迁移，并介导肿瘤相关巨噬细胞和癌细胞之间的相互作用，导致 PDL-1 介导的免疫抑制和 Nrf2 介导的上皮-间充质转化。该综述还讨论了 VEGF 参与细胞器内串扰、肿瘤代谢、干性和上皮-间充质转化的情况。它还提供了对当前抗 VEGF 治疗及其在癌症治疗中的局限性的见解。总的来说，本综述旨在全面概述目前关于 VEGF 信号及其影响的知识状况，不仅涉及血管生成，还涉及各种其他致癌过程。
