Lundgaard Karoline M, Christiansen Morten Ø, Sonne Heidi, Mose Katrine, Nyland Nikolaj, Andersen Maja J L, Pottegård Anton
Department of Public Health, Clinical Pharmacology, Pharmacy and Environmental Medicine, University of Southern Denmark, Odense, Denmark.
Basic Clin Pharmacol Toxicol. 2025 Jun;137(1):e70057. doi: 10.1111/bcpt.70057.
The global increase in proton-pump inhibitor (PPI) use has raised concerns about their appropriate use, particularly due to potential overprescription and associated adverse effects. This study examines PPI utilization patterns among Danish adults from 2015 to 2023 using the Danish nationwide health registries. We estimated the annual incidence rate (users per 100 person-years) and monthly prevalence (proportion with a filled prescription or sufficient tablets). Treatment duration was assessed using the 'proportion of patients covered' and the Kaplan-Meier method. We also calculated the proportion of adults with concomitant use of ulcerogenic drugs over time. We identified 1 729 440 adults who filled at least one PPI prescription during 2015-2023. The prevalence increased from 7.0% in 2015 to 8.2% in 2023, while incidence rate remained stable at ~3 users per 100 person years. PPI use increased with age. Three years after initiation, 17% used PPIs, while 1.5% had remained on continuous treatment. In 2023, 50% of users had concomitant ulcerogenic drug use, a 3.2% increase since 2015. The prevalence of PPI use in Denmark has risen markedly reaching a high stable level, with a clear age-dependent trend. Increased attention to appropriate PPI use is necessary to ensure rational prescribing and prevent potential overuse.
全球质子泵抑制剂（PPI）使用量的增加引发了对其合理使用的担忧，特别是由于可能存在的过度处方及相关不良反应。本研究利用丹麦全国健康登记系统，调查了2015年至2023年丹麦成年人中PPI的使用模式。我们估算了年发病率（每100人年的使用者人数）和月患病率（有已配处方或足够药片的比例）。使用“患者覆盖比例”和Kaplan-Meier方法评估治疗持续时间。我们还计算了随着时间推移同时使用致溃疡药物的成年人比例。我们确定了1729440名在2015 - 2023年期间至少开具过一张PPI处方的成年人。患病率从2015年的7.0%增至2023年的8.2%，而发病率保持稳定，约为每100人年3名使用者。PPI的使用随年龄增长而增加。开始使用三年后，17%的人使用PPI，而1.5%的人持续接受治疗。2023年，50%的使用者同时使用致溃疡药物，自2015年以来增加了3.2%。丹麦PPI的使用患病率显著上升并达到了一个高稳定水平，且有明显的年龄依赖性趋势。有必要更加关注PPI的合理使用，以确保合理处方并防止潜在的过度使用。
