Bagust J, Forsythe I D, Kerkut G A
Brain Res. 1985 Aug 26;341(2):385-9. doi: 10.1016/0006-8993(85)91080-7.
Intracellular recordings have been made from 31 primary afferent fibres within the dorsal horn of an isolated mammalian spinal cord. In 17 fibres stimulation of an adjacent dorsal root evoked primary afferent depolarization (PAD); these fibres also showed spontaneous depolarizations. Replacement of the calcium in the perfusing medium by manganese blocked both evoked and spontaneous activity showing them to be of synaptic origin. Observations on the effects of current injection and of bicuculline support an involvement of GABA in the generation of PAD.
在分离的哺乳动物脊髓背角内，对31条初级传入纤维进行了细胞内记录。在17条纤维中，刺激相邻的背根可诱发初级传入去极化（PAD）；这些纤维也表现出自发性去极化。用锰取代灌注液中的钙可阻断诱发活动和自发活动，表明它们起源于突触。关于电流注入和荷包牡丹碱作用的观察结果支持γ-氨基丁酸（GABA）参与PAD的产生。
