Bagust J, Forsythe I D, Kerkut G A, Loots J M
Brain Res. 1982 Feb 4;233(1):186-94. doi: 10.1016/0006-8993(82)90940-4.
Slow negative potentials, evoked by stimulation of the lumbar dorsal roots, have been demonstrated in the dorsal horn of an isolated, hemisected spinal cord preparation from golden hamsters. Paired stimuli revealed a period of partial suppression of this slow potential persisting for up to 2 s following the conditioning stimulus, but with high stimulation frequencies this effect was masked and above 20 Hz a tetanic train of stimuli produced a smoothly rising potential. The response evoked by tetanic stimulation was shown to consist of two components, a manganese-sensitive, synaptically generated component, and a manganese-resistant, frequency-dependent element. Treatment with 10(-4) M 4-aminopyridine blocked the manganese-resistant tetanic response but did not reduce the manganese-sensitive component. Bicuculline, picrotoxin and tubocurare had little effect upon the tetanic response, but 10(-3) M procaine blocked it completely. The possibility that the manganese-resistant response was due to the release of potassium ions is considered.
在金黄地鼠分离的半横切脊髓标本的背角中，已证实由刺激腰背根诱发的缓慢负电位。成对刺激显示，在条件刺激后，这种缓慢电位会有一段部分抑制期，持续长达2秒，但在高刺激频率下，这种效应会被掩盖，在20Hz以上，一串强直刺激会产生一个平滑上升的电位。强直刺激诱发的反应显示由两个成分组成，一个对锰敏感、由突触产生的成分，以及一个对锰有抗性、与频率相关的成分。用10⁻⁴M 4-氨基吡啶处理可阻断对锰有抗性的强直反应，但不会降低对锰敏感的成分。荷包牡丹碱、印防己毒素和筒箭毒对强直反应影响很小，但10⁻³M普鲁卡因可完全阻断它。文中考虑了对锰有抗性的反应是由于钾离子释放所致的可能性。
