Reith M E, Meisler B E, Sershen H, Lajtha A
Brain Res. 1985 Sep 2;342(1):145-8. doi: 10.1016/0006-8993(85)91363-0.
There was a highly significant correlation between IC50 values of various drugs in inhibiting the Na+-independent [3H]cocaine binding in the mouse striatum and their values in inhibiting the synaptosomal uptake of [3H]serotonin. In contrast, there was no correlation between the inhibition of binding in the absence of Na+ and the inhibition of [3H]dopamine uptake. Lesioning of serotonergic nerve terminals with 5,7-dihydroxytryptamine reduced the Na+-independent [3H]cocaine binding, without affecting the Na+-dependent binding. These results indicate that the bulk of the Na+-independent [3H]cocaine binding in the mouse striatum is associated with serotonergic nerve terminals.
多种药物在抑制小鼠纹状体中不依赖钠离子的[³H]可卡因结合方面的IC50值与其在抑制[³H]血清素突触体摄取方面的值之间存在高度显著的相关性。相比之下，在无钠离子情况下的结合抑制与[³H]多巴胺摄取抑制之间没有相关性。用5,7 - 二羟基色胺损伤血清素能神经末梢可降低不依赖钠离子的[³H]可卡因结合，而不影响依赖钠离子的结合。这些结果表明，小鼠纹状体中大部分不依赖钠离子的[³H]可卡因结合与血清素能神经末梢相关。
