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Caution with PBPK Modeling Based on the In Vitro Kinetics for Bilirubin Hepatic Uptake and Glucuronidation: Commentary on Dong et al.

作者信息

Miners John O, Polasek Thomas M

机构信息

Discipline of Clinical Pharmacology, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.

Centre for Medicine Use and Safety, Monash University, Melbourne, Victoria, Australia.

出版信息

Clin Pharmacol Ther. 2025 Aug;118(2):301-303. doi: 10.1002/cpt.3734. Epub 2025 May 26.

DOI:10.1002/cpt.3734
PMID:40418110
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12272321/
Abstract
摘要

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本文引用的文献

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2
Inhibition of OATP1B1/3 Rather Than UGT1A1 May Be the Major Cause of the Bilirubin Elevation After Atazanavir Administration.阿扎那韦给药后胆红素升高的主要原因可能是OATP1B1/3受到抑制，而非UGT1A1受到抑制。
Clin Pharmacol Ther. 2025 Aug;118(2):497-509. doi: 10.1002/cpt.3529. Epub 2024 Dec 14.
3
Static Versus Dynamic Model Predictions of Competitive Inhibitory Metabolic Drug-Drug Interactions via Cytochromes P450: One Step Forward and Two Steps Backwards.通过细胞色素P450对竞争性抑制性代谢药物-药物相互作用的静态与动态模型预测：前进一步，后退两步。
Clin Pharmacokinet. 2025 Jan;64(1):155-170. doi: 10.1007/s40262-024-01457-1. Epub 2024 Dec 10.
4
Drug-drug interactions that alter the exposure of glucuronidated drugs: Scope, UDP-glucuronosyltransferase (UGT) enzyme selectivity, mechanisms (inhibition and induction), and clinical significance.药物-药物相互作用改变葡萄糖醛酸化药物的暴露：范围、尿苷二磷酸葡萄糖醛酸转移酶（UGT）酶选择性、机制（抑制和诱导）以及临床意义。
Pharmacol Ther. 2023 Aug;248:108459. doi: 10.1016/j.pharmthera.2023.108459. Epub 2023 May 30.
5
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Pharmacol Ther. 2021 Feb;218:107689. doi: 10.1016/j.pharmthera.2020.107689. Epub 2020 Sep 25.
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