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Caution with PBPK Modeling Based on the In Vitro Kinetics for Bilirubin Hepatic Uptake and Glucuronidation: Commentary on Dong et al.

作者信息

Miners John O, Polasek Thomas M

机构信息

Discipline of Clinical Pharmacology, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.

Centre for Medicine Use and Safety, Monash University, Melbourne, Victoria, Australia.

出版信息

Clin Pharmacol Ther. 2025 Aug;118(2):301-303. doi: 10.1002/cpt.3734. Epub 2025 May 26.

Abstract
摘要

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本文引用的文献

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7
Bilirubin glucuronidation revisited: proper assay conditions to estimate enzyme kinetics with recombinant UGT1A1.
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8
Characterization of the UDP glucuronosyltransferase activity of human liver microsomes genotyped for the UGT1A1*28 polymorphism.
Drug Metab Dispos. 2007 Dec;35(12):2270-80. doi: 10.1124/dmd.107.017806. Epub 2007 Sep 26.
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Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6.
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