Kościńska-Shukla Iga, Jaskólska Marta, Grochowalska Kinga, Okrój Marcin, Chmielewski Michał
Department of Rheumatology, Clinical Immunology, Geriatrics and Internal Medicine, Medical University of Gdańsk, Gdańsk, Poland.
Department of Cell Biology and Immunology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, Gdańsk, Poland.
Rheumatol Int. 2025 May 26;45(6):144. doi: 10.1007/s00296-025-05900-9.
The impact of vitamin B complex has long been studied and utilized in clinical practice, both for healthy and diseased individuals. Its beneficial effects on physical and mental performance have been proven by multiple studies leading to widespread supplementation among the general population. As of today's knowledge, vitamin B6 (pyridoxine) in excessive doses may lead to symptoms of neuropathy. Unfortunately, many of those supplementing vitamin B complex are unaware of such a risk. This case-based review presents three patients who initially searched for help due to neuropathic symptoms with the rheumatological diagnostic process following. All of them had a history of excessive vitamin B6 consumption, though through different sources. Cessation of supplementation led to prompt improvement in symptoms. These cases stress the importance of in-depth history taking and specifying instructions regarding prescribed supplements. The novelty of this article lies in the description of a patient who reported symptoms associated with central nervous system with concomitant abnormalities of the complement system, all of which resolved spontaneously upon normalization of pyridoxine concentration.
复合维生素B的影响长期以来一直被研究并应用于临床实践，无论是健康人群还是患病个体。多项研究已证实其对身体和心理表现有益，这导致普通人群中广泛使用该补充剂。就目前的认知而言，过量摄入维生素B6（吡哆醇）可能会导致神经病变症状。不幸的是，许多服用复合维生素B的人并未意识到这种风险。本病例回顾介绍了三名患者，他们最初因神经病变症状寻求帮助，随后进行了风湿病诊断流程。他们都有过量摄入维生素B6的病史，尽管来源不同。停止补充后症状迅速改善。这些病例强调了详细询问病史以及明确规定补充剂使用说明的重要性。本文的新颖之处在于描述了一名报告伴有中枢神经系统症状且补体系统异常的患者，所有这些症状在吡哆醇浓度恢复正常后均自发缓解。
