Totapally Balagangadhar R, Totapalli Seevitha, Malhotra-Hans Anushree, Meyer Keith
Division of Critical Care Medicine, Nicklaus Children's Hospital, 3100 SW 62nd Avenue, Miami, FL, 33155, USA.
Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
Pediatr Cardiol. 2025 May 26. doi: 10.1007/s00246-025-03907-4.
Cardiac tumors in children, although rare, can lead to obstruction of valves or cardiac conduction problems. Large multi-site or national data on pediatric cardiac tumors is lacking. The objective of this study was to determine the prevalence of primary cardiac tumors in hospitalized children from 1997 to 2019 in the US and analyze the demographic and clinical characteristics of children with cardiac tumors. We conducted a cross-sectional analysis using the Healthcare Cost and Utilization Project's Kid's Inpatient Database from 1997 to 2019. Children with cardiac tumors were identified using ICD-9 and ICD-10 diagnosis codes. The prevalence is presented per 100,000 hospital discharges and 1,000,000 age-specific US population. The Chi-square test was used to compare the discharges with and without cardiac tumors for demographic and clinical variables. The Chi-square for linear trend (Extended Mantel-Haenszel) test was used for trend analyses. There were 3,166 discharges with primary cardiac tumors out of a total of 55.1 million discharges with a hospitalization rate of 5.8 per 100,000 discharges and 4.82 per million US children. Out of all children with cardiac tumors, 29.9% were neonates, 20.7% were infants, and 71% were children less than 5 years of age. Males comprised 52.9% of all cases. An increase in the prevalence of cardiac tumors from 1997 to 2019 was observed (p < 0.001). Of all admissions with cardiac tumors, 88.9% were reported benign, and 37.3% were admitted to Children's Hospitals. Cardiac arrhythmias were reported in 19.2%, seizures in 28%, and stroke in 1.4%. 51.9% of cases were associated with tuberous sclerosis. Cardiac surgical procedures were performed in 13.9% of patients. The overall hospital mortality rate was 1.6%. Primary cardiac tumor is a rare condition in children and is most common in neonates and young children. Most pediatric cardiac tumors are benign, and many are associated with tuberous sclerosis.
儿童心脏肿瘤虽然罕见，但可导致瓣膜梗阻或心脏传导问题。目前缺乏关于小儿心脏肿瘤的大型多中心或全国性数据。本研究的目的是确定1997年至2019年美国住院儿童中原发性心脏肿瘤的患病率，并分析心脏肿瘤患儿的人口统计学和临床特征。我们使用1997年至2019年医疗保健成本和利用项目的儿童住院数据库进行了横断面分析。使用ICD - 9和ICD - 10诊断代码识别心脏肿瘤患儿。患病率以每10万次出院和每100万特定年龄的美国人口来表示。采用卡方检验比较有和没有心脏肿瘤的出院病例的人口统计学和临床变量。采用线性趋势卡方检验（扩展Mantel - Haenszel检验）进行趋势分析。在总共5510万次出院病例中，有3166例原发性心脏肿瘤出院病例，住院率为每10万次出院5.8例，每百万美国儿童4.82例。在所有患有心脏肿瘤的儿童中，29.9%为新生儿，20.7%为婴儿，71%为5岁以下儿童。男性占所有病例的52.9%。观察到1997年至2019年心脏肿瘤患病率有所上升（p < 0.001）。在所有心脏肿瘤入院病例中，88.9%报告为良性，37.3%入住儿童医院。报告有心律失常的占19.2%，癫痫发作的占28%，中风的占1.4%。51.9%的病例与结节性硬化症有关。13.9%的患者接受了心脏外科手术。总体医院死亡率为1.6%。原发性心脏肿瘤在儿童中是一种罕见疾病，在新生儿和幼儿中最为常见。大多数小儿心脏肿瘤是良性的，许多与结节性硬化症有关。
