Aelvoet Arthur S, Shimamoto Yusaku, Takeuchi Yoji, Dekker Evelien, Burke Carol A, Kupfer Sonia S, Mankaney Gautam
Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Cancer Center Amsterdam, Amsterdam, The Netherlands.
Fam Cancer. 2025 May 26;24(2):49. doi: 10.1007/s10689-025-00472-w.
Colorectal cancer can be prevented in most patients with FAP by performing (procto)colectomy and lifelong endoscopic surveillance. Subsequently, the challenge is to prevent duodenal and gastric cancer. Duodenal cancer is one of the most common FAP-related causes of death and, in the last decade, the incidence of gastric cancer has increased. Performing frequent endoscopic surveillance with removal of neoplasia is important to prevent cancer especially since cancers in the upper GI tract generally have a poor prognosis. Moreover, the goal is to prevent upper GI surgery as these procedures are associated with substantial morbidity. In this review, we provide the prevalence of upper GI polyposis and cancer, describe endoscopic and histologic features, and discuss strategies for surveillance and treatment.
对于大多数家族性腺瘤性息肉病（FAP）患者，通过实施（直肠）结肠切除术和终身内镜监测可预防结直肠癌。随后，面临的挑战是预防十二指肠癌和胃癌。十二指肠癌是FAP相关的最常见死亡原因之一，并且在过去十年中，胃癌的发病率有所上升。频繁进行内镜监测并切除肿瘤对于预防癌症很重要，特别是因为上消化道癌症通常预后较差。此外，目标是避免进行上消化道手术，因为这些手术会带来较高的发病率。在本综述中，我们提供上消化道息肉病和癌症的患病率，描述内镜和组织学特征，并讨论监测和治疗策略。
