Rasmussen K, Jacobs B L
Brain Res. 1985 Oct 7;344(2):240-8. doi: 10.1016/0006-8993(85)90801-7.
Contrary to previous reports of morphine's depression of locus coeruleus (LC) unit activity in anesthetized animals, acute administration of morphine (0.5, 2.0 or 4.0 mg/kg, i.p.) did not decrease the unit activity of noradrenergic neurons in the area of the LC of freely moving cats. In fact at the higher doses examined (2.0 and 4.0 mg/kg) morphine significantly increased unit activity. Naloxone (1 mg/kg, i.p.) administration reversed the increase in unit activity produced by morphine. When these same studies were conducted in cats first anesthetized with chloral hydrate, morphine produced a significant decrease in unit activity in a naloxone-reversible manner. These results suggest that previous reports of systemic morphine's depression of LC unit activity may be at least partially attributable to an interaction with anesthesia. Morphine's multiplicity of actions upon the LC is discussed.
与之前关于吗啡抑制麻醉动物蓝斑（LC）单位活动的报道相反，对自由活动的猫腹腔注射吗啡（0.5、2.0或4.0 mg/kg），并未降低LC区域去甲肾上腺素能神经元的单位活动。事实上，在较高剂量（2.0和4.0 mg/kg）下，吗啡显著增加了单位活动。腹腔注射纳洛酮（1 mg/kg）可逆转吗啡引起的单位活动增加。当对先用氯醛水合氯醛麻醉的猫进行同样的研究时，吗啡以纳洛酮可逆的方式显著降低了单位活动。这些结果表明，之前关于全身应用吗啡抑制LC单位活动的报道可能至少部分归因于与麻醉的相互作用。文中讨论了吗啡对LC的多种作用。
