Napier T C, Pirch J H, Peterson S L
Neuropharmacology. 1983 Feb;22(2):165-71. doi: 10.1016/0028-3908(83)90004-7.
The effect of systemically administered morphine on spontaneous unit activity, recorded from the globus pallidus, was evaluated in this study. A wide range of doses of morphine was administered in order to characterize the influences of morphine on pallidal activity in a dose-related manner. Two separate studies were conducted. In the first study, a semichronic preparation, lightly anesthetized with phenobarbitol, was used. Acutely prepared, chloral hydrate-anesthetized rats were utilized in the second experiment. With phenobarbital, morphine caused a significant reduction in pallidal activity in 75% of the cells recorded, whereas only 45% of the pallidal cells responded similarly to injection of morphine in chloral hydrate-anesthetized animals. However, the dose of morphine required to decrease unit activity was substantially less with chloral hydrate than with phenobarbital anesthesia.
本研究评估了全身给药吗啡对从苍白球记录到的自发单位活动的影响。给予了广泛范围的吗啡剂量，以便以剂量相关的方式表征吗啡对苍白球活动的影响。进行了两项独立的研究。在第一项研究中，使用了用苯巴比妥轻度麻醉的半慢性制备方法。在第二项实验中使用了急性制备的、水合氯醛麻醉的大鼠。使用苯巴比妥时，吗啡使75%记录的细胞的苍白球活动显著降低，而在水合氯醛麻醉的动物中，只有45%的苍白球细胞对注射吗啡有类似反应。然而，与苯巴比妥麻醉相比，水合氯醛降低单位活动所需的吗啡剂量要少得多。
