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纳洛酮诱导的吗啡耐受大鼠伤害性感受测试阈值升高。

Increase in the threshold of a nociceptive test induced by naloxone in morphine-tolerant rats.

作者信息

Kayser V, Guilbaud G

出版信息

Brain Res. 1985 Oct 7;344(2):360-4. doi: 10.1016/0006-8993(85)90815-7.

DOI:10.1016/0006-8993(85)90815-7
PMID:4041883
Abstract

The effects of various doses of naloxone (3-1000 micrograms/kg i.v.) on the vocalization threshold elicited by pressure on the paw were evaluated in rats chronically treated with high doses of morphine. In addition to the well known precipitation of withdrawal induced by naloxone, an unexpected dose-related increase in the vocalization threshold was observed.

摘要

在长期接受高剂量吗啡治疗的大鼠中，评估了不同剂量的纳洛酮（静脉注射3 - 1000微克/千克）对 paw 部压力引起的发声阈值的影响。除了众所周知的纳洛酮诱发戒断反应外，还观察到发声阈值出现了意外的剂量相关增加。 （注：原文中“paw”直接保留英文未翻译，可能是特定医学术语或有误，这里按原样呈现。）

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