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极低剂量全身性吗啡在持续性疼痛动物模型（弗氏佐剂诱导的关节炎大鼠）中的反常痛觉过敏效应

Paradoxical hyperalgesic effect of exceedingly low doses of systemic morphine in an animal model of persistent pain (Freund's adjuvant-induced arthritic rats).

作者信息

Kayser V, Besson J M, Guilbaud G

出版信息

Brain Res. 1987 Jun 23;414(1):155-7. doi: 10.1016/0006-8993(87)91338-2.

DOI:10.1016/0006-8993(87)91338-2
PMID:3620918
Abstract

The effects of exceedingly low doses of morphine (3-50 micrograms/kg i.v.) were studied upon the vocalization threshold induced by paw pressure in rats with Freund's adjuvant-induced arthritis. The highest dose used (50 micrograms/kg i.v.) clearly induced an analgesic effect. No significant modification of the vocalization threshold was observed with 30 micrograms/kg. By contrast, a significant hyperalgesic effect resulted with doses of 10 down to 3 micrograms/kg. Maximum hyperalgesia was observed with 6 micrograms/kg.

摘要

研究了极低剂量吗啡（静脉注射3 - 50微克/千克）对弗氏佐剂诱导性关节炎大鼠 paw 压力诱导的发声阈值的影响。所使用的最高剂量（静脉注射50微克/千克）明显诱导了镇痛作用。30微克/千克剂量未观察到发声阈值的显著改变。相比之下，10微克/千克至3微克/千克剂量产生了显著的痛觉过敏效应。6微克/千克时观察到最大痛觉过敏。

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