Flood D G, Buell S J, Defiore C H, Horwitz G J, Coleman P D
Brain Res. 1985 Oct 21;345(2):366-8. doi: 10.1016/0006-8993(85)91018-2.
Dendritic extent in dentate gyrus granule cells of normal aging human brain was found to increase between middle age (fifties) and early old age (seventies). However, dendritic regression was found in the oldest old (nineties). This finding of dendritic regression following growth is in contrast to previous quantitative reports of continued dendritic growth in parahippocampal gyrus of aging human brain. This new result reinforces the concept of age and region specificity in changes in dendritic extent.
研究发现，正常衰老的人类大脑齿状回颗粒细胞的树突范围在中年（五十多岁）到老年早期（七十多岁）之间会增加。然而，在最年长的老人（九十多岁）中发现了树突退化现象。这种生长后出现树突退化的发现与之前关于衰老人类大脑海马旁回树突持续生长的定量报告形成了对比。这一新结果强化了树突范围变化中年龄和区域特异性的概念。
