认知衰老的保守调节因子：从蠕虫到人类。
Conserved regulators of cognitive aging: From worms to humans.
作者信息
Arey Rachel N, Murphy Coleen T
机构信息
Department of Molecular Biology & LSI Genomics, Princeton University, Princeton, NJ 08544, United States.
Department of Molecular Biology & LSI Genomics, Princeton University, Princeton, NJ 08544, United States.
出版信息
Behav Brain Res. 2017 Mar 30;322(Pt B):299-310. doi: 10.1016/j.bbr.2016.06.035. Epub 2016 Jun 18.
Abstract
Cognitive decline is a major deficit that arises with age in humans. While some research on the underlying causes of these problems can be done in humans, harnessing the strengths of small model systems, particularly those with well-studied longevity mutants, such as the nematode C. elegans, will accelerate progress. Here we review the approaches being used to study cognitive decline in model organisms and show how simple model systems allow the rapid discovery of conserved molecular mechanisms, which will eventually enable the development of therapeutics to slow cognitive aging.
摘要
认知衰退是人类随着年龄增长而出现的一个主要缺陷。虽然可以在人类身上对这些问题的潜在原因进行一些研究，但利用小型模型系统的优势，特别是那些具有经过充分研究的长寿突变体的系统，如线虫秀丽隐杆线虫，将加速研究进展。在这里，我们综述了用于研究模式生物认知衰退的方法，并展示了简单的模型系统如何能够快速发现保守的分子机制，这最终将有助于开发减缓认知衰老的疗法。
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