Aziz Yasir, Chen Yong Mei, Li Peng Cheng, Xi Yi Fang, Song He Ming, Zhao Jia, Bi Meng Liang, Li Jian Hui, Li Hao Peng, Miyatake Hideyuki, Ito Yoshihiro, Zrínyi Miklós, Jin Hongxu
College of Bioresources Chemical and Materials Engineering, National Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi University of Science and Technology, Xi'an 710021, PR China.
College of Bioresources Chemical and Materials Engineering, National Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi University of Science and Technology, Xi'an 710021, PR China.
Int J Biol Macromol. 2025 Jun;316(Pt 1):144591. doi: 10.1016/j.ijbiomac.2025.144591. Epub 2025 May 24.
Biomacromolecules based injectable and self-healing hydrogels are promising soft biomaterials with dynamic and reversible features. Yet, it remains a challenge to achieve both high mechanical strength and dynamic behavior. Here, we present a tough dynamic nanocomposite hydrogel (FeO/PDA@OSA-l-Gel) fabricated by incorporating polydopamine coated iron oxide nanoparticles (FeO/PDA NPs) into dynamically crosslinked biomacromolecular networks of oxidized sodium alginate (OSA) and gelatin (Gel) in the presence of borax. The loading of FeO/PDA NPs significantly enhances the mechanical properties of dynamic nanocomposite hydrogel exhibiting excellent injectable and self-healing properties. The synergistic effect of multiple dynamic chemical bonds (e.g., imine bond, borate ester bond) and physical interactions (e.g., electrostatic interaction, hydrogen bond) that enable excellent mechanical properties (3.78 MPa compressive strength, 674.72 J/m energy dissipation and 109.1 kJ/m toughness). FeO/PDA NPs play the role of killing two birds with one stone, i.e., act as a nano-crosslinker to enhance mechanical properties of the dynamic nanocomposite hydrogel, and as a carrier for sustained protein release. Furthermore, the dynamic nanocomposite hydrogel exhibits good hemocompatibility and cytocompatibility. This work highlights the novel strategy for doping mussel inspired nanoparticles into dynamic hydrogel networks to enhance mechanical properties and sustain protein release.
基于生物大分子的可注射且自愈合水凝胶是具有动态和可逆特性的有前途的软生物材料。然而，要同时实现高机械强度和动态行为仍然是一个挑战。在此，我们展示了一种坚韧的动态纳米复合水凝胶（FeO/PDA@OSA-l-Gel），它是通过在硼砂存在的情况下，将聚多巴胺包覆的氧化铁纳米颗粒（FeO/PDA NPs）掺入氧化海藻酸钠（OSA）和明胶（Gel）的动态交联生物大分子网络中制备而成。FeO/PDA NPs的负载显著增强了动态纳米复合水凝胶的机械性能，使其具有优异的可注射和自愈合性能。多种动态化学键（如亚胺键、硼酸酯键）和物理相互作用（如静电相互作用、氢键）的协同作用赋予了其优异的机械性能（3.78兆帕的抗压强度、674.72焦/米的能量耗散和109.1千焦/米的韧性）。FeO/PDA NPs起到了一石二鸟的作用，即作为纳米交联剂增强动态纳米复合水凝胶的机械性能，并作为持续蛋白质释放的载体。此外，动态纳米复合水凝胶表现出良好的血液相容性和细胞相容性。这项工作突出了将贻贝启发的纳米颗粒掺入动态水凝胶网络以增强机械性能和持续蛋白质释放的新策略。
