Xiang Yushuang, Wang Zhiruo, Xu Jing, Wang Jie, Wu Chaoming, Pan Youjin
Wenzhou Medical University, Wenzhou, 325000, China.
Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
BMC Endocr Disord. 2025 Jan 26;25(1):20. doi: 10.1186/s12902-025-01846-y.
The Weight-adjusted-waist index (WWI) has emerged as a predictive factor for a range of metabolic disorders. To date, the predictive value of the WWI in relation to sarcopenia in individuals with diabetics has not been extensively explored. This study aims to investigate the impact of the WWI on the prevalence of sarcopenia among patients with type 2 diabetes mellitus (T2DM).
In this study, we enrolled 417 patients with T2DM from the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University between Dec. 2023 and Apr. 2024. The relationship between the WWI and the prevalence of sarcopenia in T2DM patients was evaluated using multivariate logistic regression, subgroup analysis, restricted cubic spline (RCS) analysis, and receiver operating characteristic (ROC) curve analysis.
Among the 417 patients with T2DM, 76 (18.22%) were identified as having sarcopenia. The prevalence of sarcopenia across the WWI quartile categories, from the first to the fourth quartile, was 8.65%, 8.57%, 20.19% and 8.65% respectively. Multivariate logistic regression analysis revealed that, after adjusting for covariates, a higher WWI was an independent risk factor for sarcopenia in male T2DM patients (OR = 1.836, 95% CI: 1.216-2.772, P = 0.004). This association was not observed in female patients. Subgroup analysis further revealed a stronger correlation between WWI and sarcopenia among male patients with higher HbA1c levels. In males, RCS regression demonstrated a non-linear positive correlation, with an inflection point at a WWI of 10.42 cm/√kg. Finally, the area under the ROC curve (AUC) for the WWI was 0.612.
WWI emerges as a robust and independent risk factor for sarcopenia in male patients with T2DM. WWI may serve as an accessible and cost-effective tool for identify sarcopenia in patients with diabetes.
体重调整腰围指数（WWI）已成为一系列代谢紊乱的预测因素。迄今为止，WWI在糖尿病患者中与肌肉减少症的预测价值尚未得到广泛研究。本研究旨在探讨WWI对2型糖尿病（T2DM）患者肌肉减少症患病率的影响。
在本研究中，我们于2023年12月至2024年4月期间，从温州医科大学附属第二医院和育英儿童医院招募了417例T2DM患者。采用多因素逻辑回归、亚组分析、限制性立方样条（RCS）分析和受试者工作特征（ROC）曲线分析，评估WWI与T2DM患者肌肉减少症患病率之间的关系。
在417例T2DM患者中，76例（18.22%）被确定患有肌肉减少症。WWI四分位数类别中，从第一四分位数到第四四分位数，肌肉减少症的患病率分别为8.65%、8.57%、20.19%和8.65%。多因素逻辑回归分析显示，在调整协变量后，较高的WWI是男性T2DM患者肌肉减少症的独立危险因素（OR = 1.836，95% CI：1.216 - 2.772，P = 0.004）。在女性患者中未观察到这种关联。亚组分析进一步显示，在糖化血红蛋白水平较高的男性患者中，WWI与肌肉减少症之间的相关性更强。在男性中，RCS回归显示为非线性正相关，拐点处的WWI为10.42 cm/√kg。最后，WWI的ROC曲线下面积（AUC）为0.612。
WWI是男性T2DM患者肌肉减少症的一个有力且独立的危险因素。WWI可能是一种用于识别糖尿病患者肌肉减少症的便捷且经济有效的工具。
