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用于评估口蹄疫疫苗区域相关性的抗原组。

An antigen panel to assess the regional relevance of foot and mouth disease vaccines.

作者信息

Paton David J, Wilsden Ginette, Browning Clare Fj, Foglia Efrem A, Di Nardo Antonello, Knowles Nick J, Wadsworth Jemma, Gubbins Simon, Chitsungo Ethel, Boukary Cisse Rahamatou Moustapha, Ayelet Gelagay, Bodjo Charles S, Nwankpa Nick, Brocchi Emiliana, Grazioli Santina, Ludi Anna, King Donald P

机构信息

The Pirbright Institute, Pirbright, Woking, Surrey, United Kingdom.

Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna, Brescia, Italy.

出版信息

NPJ Vaccines. 2025 May 26;10(1):106. doi: 10.1038/s41541-025-01128-7.

DOI:10.1038/s41541-025-01128-7
PMID:40419503
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12106609/
Abstract

Despite widespread use of inactivated vaccines to control foot-and-mouth disease (FMD), there is no systematic approach to demonstrate the regional relevance of these products against the specific serotypes and strains that circulate in endemic countries in Africa and Asia. Failure to adopt independent testing of FMD vaccines has contributed to poor trust in their quality and a lack of investment in vaccination programmes. Therefore, a reference antigen panel representing four serotypes, tailored for East Africa, has been established and used to measure FMDV-specific antibody responses in cattle after administration of FMD vaccines commercially available in the region. This revealed inconsistencies and gaps in cross-neutralisation responses that are evident for some vaccines even after giving booster doses. It is concluded that the East Africa reference antigen panel can be used to evaluate FMD vaccine potency and drive up vaccine quality. Further panels could be developed and deployed for other endemic regions.

摘要

尽管灭活疫苗被广泛用于控制口蹄疫（FMD），但尚无系统方法来证明这些产品对非洲和亚洲流行国家中传播的特定血清型和毒株的区域相关性。未能对口蹄疫疫苗进行独立检测导致人们对其质量缺乏信任，且疫苗接种计划缺乏投资。因此，已建立了一个针对东非量身定制的、代表四种血清型的参考抗原组，并用于测量该地区市售口蹄疫疫苗接种后牛体内口蹄疫病毒特异性抗体反应。这揭示了交叉中和反应中的不一致性和差距，即使在给予加强剂量后，某些疫苗的这些问题仍然明显。得出的结论是，东非参考抗原组可用于评估口蹄疫疫苗效力并提高疫苗质量。还可以为其他流行地区开发和部署更多的参考抗原组。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb79/12106609/1e456cdabfe4/41541_2025_1128_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb79/12106609/0607953843fe/41541_2025_1128_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb79/12106609/556772c106bb/41541_2025_1128_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb79/12106609/206e5d3de0a5/41541_2025_1128_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb79/12106609/b6fc6ab4e66b/41541_2025_1128_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb79/12106609/4db16df5d06d/41541_2025_1128_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb79/12106609/1e456cdabfe4/41541_2025_1128_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb79/12106609/0607953843fe/41541_2025_1128_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb79/12106609/556772c106bb/41541_2025_1128_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb79/12106609/206e5d3de0a5/41541_2025_1128_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb79/12106609/b6fc6ab4e66b/41541_2025_1128_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb79/12106609/4db16df5d06d/41541_2025_1128_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb79/12106609/1e456cdabfe4/41541_2025_1128_Fig6_HTML.jpg

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本文引用的文献

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Emerg Infect Dis. 2025 Feb;31(2):368-372. doi: 10.3201/eid3102.240395.
2
Evaluation of commercial quadrivalent foot-and-mouth disease vaccines against east African virus strains reveals limited immunogenicity and duration of protection.针对东非病毒株的商用四价口蹄疫疫苗评估显示免疫原性和保护持续时间有限。
Vaccine. 2024 Dec 2;42(26):126325. doi: 10.1016/j.vaccine.2024.126325. Epub 2024 Sep 12.
3
Predicting cross-protection against foot-and-mouth disease virus strains by serology after vaccination.
接种疫苗后通过血清学预测对口蹄疫病毒株的交叉保护作用。
Front Vet Sci. 2022 Dec 1;9:1027006. doi: 10.3389/fvets.2022.1027006. eCollection 2022.
4
Genotyping of foot-and-mouth disease viruses collected in Sudan between 2009 and 2018.2009 年至 2018 年期间在苏丹采集的口蹄疫病毒的基因分型。
Transbound Emerg Dis. 2022 Sep;69(5):e1393-e1406. doi: 10.1111/tbed.14472. Epub 2022 Feb 23.
5
Targeted FMD Vaccines for Eastern Africa: The AgResults Foot and Mouth Disease Vaccine Challenge Project.东非目标口蹄疫疫苗：AgResults 口蹄疫疫苗挑战项目。
Viruses. 2021 Sep 14;13(9):1830. doi: 10.3390/v13091830.
6
Inter-laboratory comparison of 2 ELISA kits used for foot-and-mouth disease virus nonstructural protein serology.用于口蹄疫病毒非结构蛋白血清学的 2 种 ELISA 试剂盒的实验室间比较。
J Vet Diagn Invest. 2020 Nov;32(6):933-937. doi: 10.1177/1040638720962070. Epub 2020 Oct 7.
7
Molecular characterization of foot-and-mouth disease viruses circulating in Ethiopia between 2008 and 2019.2008 年至 2019 年期间在埃塞俄比亚流行的口蹄疫病毒的分子特征。
Transbound Emerg Dis. 2020 Nov;67(6):2983-2992. doi: 10.1111/tbed.13675. Epub 2020 Jul 1.
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Towards improvements in foot-and-mouth disease vaccine performance.致力于提高口蹄疫疫苗的性能。
Acta Vet Scand. 2020 May 20;62(1):20. doi: 10.1186/s13028-020-00519-1.
9
IQ-TREE 2: New Models and Efficient Methods for Phylogenetic Inference in the Genomic Era.IQ-TREE 2：基因组时代系统发育推断的新模型和有效方法。
Mol Biol Evol. 2020 May 1;37(5):1530-1534. doi: 10.1093/molbev/msaa015.
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Estimating the protection afforded by foot-and-mouth disease vaccines in the laboratory.估算口蹄疫疫苗在实验室中提供的保护力。
Vaccine. 2019 Sep 3;37(37):5515-5524. doi: 10.1016/j.vaccine.2019.07.102. Epub 2019 Aug 9.