Hani Umme, Mahammed Nawaz, Reshma T, Talath Sirajunisa, Wali Adil Farooq, Aljasser Abdullah, Al Fatease Adel, Alamri Ali H, Khan Sharuk
Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha, 62529, Saudi Arabia.
Department of Pharmaceutics, Raghavendra Institute of Pharmaceutical Education and Research, K.R. Palli Cross, Anantapur, Chiyyedu, 515721, Andhra Pradesh, India.
Sci Rep. 2025 May 26;15(1):18355. doi: 10.1038/s41598-025-03533-3.
This study explored the development of a novel colon-specific drug delivery system for 5-fluorouracil (5-FU) using cross-linked mastic gum (MG) nanoparticles (NPs). The primary goal is to enhance the treatment efficacy of colon cancer while minimizing systemic side effects. We employed Fourier Transform Infrared Radiation (FTIR) and Scanning Electron Microscopy (SEM) for the detailed characterization of the samples. FTIR analysis confirmed the successful cross-linking of MG, whereas SEM images revealed the spherical and uniform morphology of the NPs. Additionally, analysis of drug encapsulation efficiency (83.53%), particle size (240 nm), and drug release kinetics (zero-order), and the drug release percentage (95.20% ) were analyzed. The results demonstrated that MG NPs effectively encapsulated and controlled the release of 5-FU in a colon-targeted manner. This study recommends the proposed drug delivery system because of its potential to improve the outcomes of colon cancer treatment.
本研究探索了一种使用交联乳香胶（MG）纳米颗粒（NPs）的新型5-氟尿嘧啶（5-FU）结肠特异性给药系统的开发。主要目标是提高结肠癌的治疗效果，同时将全身副作用降至最低。我们采用傅里叶变换红外辐射（FTIR）和扫描电子显微镜（SEM）对样品进行详细表征。FTIR分析证实了MG的成功交联，而SEM图像显示了NPs的球形和均匀形态。此外，还分析了药物包封率（83.53%）、粒径（240nm）、药物释放动力学（零级）和药物释放百分比（95.20%）。结果表明，MG NPs以结肠靶向方式有效包封并控制了5-FU的释放。由于该给药系统具有改善结肠癌治疗效果 的潜力，本研究推荐了该给药系统。
