Thaw Yu Nandi, Charoenkul Kamonpan, Nasamran Chanakarn, Chamsai Ekkapat, Jairak Waleemas, Phyu Eaint Min, Phyu Hnin Wai, Chaiyawong Supassama, Amonsin Alongkorn
Department of Veterinary Public Health, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, 10330, Thailand.
Center of Excellence for Emerging and Re-emerging Infectious Diseases in Animals, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.
Sci Rep. 2025 May 26;15(1):18293. doi: 10.1038/s41598-025-03037-0.
Astrovirus (AstV) is an RNA virus that causes gastroenteritis in humans and various mammal species, including dogs and cats. In this study, we conducted a survey of canine and feline astroviruses in domestic dogs and cats in Bangkok and its vicinity in Thailand. From January 2022 to December 2023, we collected a total of 1,498 rectal swab samples from domestic dogs (n = 862) and cats (n = 636) at private small animal hospitals in Bangkok, Nonthaburi, and Samut Prakran, Thailand. The positive rate for canine astrovirus (CaAstV) was 4.2% (36/862), while that of feline astrovirus (FeAstV) in cats was 10.8% (69/636). We performed complete genome sequencing of Thai-CaAstVs (n = 11) and Thai-FeAstVs (n = 12). Phylogenetic analysis revealed that Thai-CaAstVs were clustered into lineages 1, 3, and 4, while Thai-FeAstVs were grouped within FeAstV group 1. This study identifies novel CaAstV lineages in domestic dogs and represents the first molecular detection of FeAstV in cats in Thailand. Our findings provide detailed information on the genetic characteristics of CaAstVs and FeAstVs currently circulating in Thailand, highlighting challenges for potential diagnostics and future control strategies.
星状病毒（AstV）是一种RNA病毒，可导致人类以及包括狗和猫在内的各种哺乳动物患上肠胃炎。在本研究中，我们对泰国曼谷及其周边地区的家犬和家猫中的犬猫星状病毒进行了调查。从2022年1月至2023年12月，我们在泰国曼谷、暖武里府和沙没巴干府的私立小型动物医院共采集了1498份家犬（n = 862）和家猫（n = 636）的直肠拭子样本。犬星状病毒（CaAstV）的阳性率为4.2%（36/862），而猫星状病毒（FeAstV）在猫中的阳性率为10.8%（69/636）。我们对泰国犬星状病毒（n = 11）和泰国猫星状病毒（n = 12）进行了全基因组测序。系统发育分析表明，泰国犬星状病毒聚类为1、3和4支系，而泰国猫星状病毒则归为猫星状病毒第1组。本研究鉴定出了家犬中的新型犬星状病毒支系，并代表了泰国首次对猫星状病毒进行分子检测。我们的研究结果提供了目前在泰国流行的犬星状病毒和猫星状病毒的遗传特征详细信息，突出了潜在诊断和未来控制策略面临的挑战。
