Jiang Qinghu, Zou Hua, Zhong Furui, Ma Jian
Department of Hepatobiliary Surgery, Dazhou Integrated TCM & Western Medicine Hospital, Dazhou, Sichuan, 635000, China.
Department of General Surgery, Zigong Fourth People's Hospital, Zigong, Sichuan, China.
BMC Pharmacol Toxicol. 2025 May 26;26(1):109. doi: 10.1186/s40360-025-00944-w.
To investigate the effect of perioperative probiotics on prognosis in patients with hepatectomy.
By conducting a computer-based search of electronic databases to collect randomized controlled trials (RCTs) on the use of probiotics in the perioperative period for patients undergoing liver resection. Two researchers independently screened the literature, extracted data, assessed bias risk, and performed a meta-analysis using RevMan 5.4 software.
A total of 988 patients were enrolled across 14 studies. The results of the meta-analysis revealed that the probiotics group had lower rates of postoperative infectious complications (OR = 0.49; 95%CI 0.49 to 0.60; P < 0.01), serum endotoxin levels (SMD= -0.69; 95%CI -1.27 to -0.11; P = 0.02), white blood cell counts (SMD= -0.37; 95%CI -0.67 to -0.061.47; P = 0.02), hospital stays (SMD= -0.85; 95%CI -1.53 to -0.18; P = 0.01), and first postoperative exhaust times (SMD= -0.85; 95%CI -1.53 to -0.18; P = 0.01) compared to the control group. No significant differences in liver function indices (alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBiL) and international normalized ratio (INR)) or postoperative inflammatory markers (C-reactive protein (CRP), procalcitonin, interleukin-6 (IL-6)) were found between the two groups (all P > 0.05).
Probiotics used perioperatively can lower postoperative infection risk and shorten hospital stays for hepatectomy patients, but they do not appear to aid in liver function restoration or inflammation reduction.
Not applicable.
探讨围手术期使用益生菌对肝切除患者预后的影响。
通过计算机检索电子数据库，收集关于益生菌在肝切除患者围手术期应用的随机对照试验（RCT）。两名研究人员独立筛选文献、提取数据、评估偏倚风险，并使用RevMan 5.4软件进行荟萃分析。
14项研究共纳入988例患者。荟萃分析结果显示，与对照组相比，益生菌组术后感染并发症发生率较低（OR = 0.49；95%CI 0.49至0.60；P < 0.01），血清内毒素水平较低（SMD = -0.69；95%CI -1.27至-0.11；P = 0.02），白细胞计数较低（SMD = -0.37；95%CI -0.67至-0.061.47；P = 0.02），住院时间较短（SMD = -0.85；95%CI -1.53至-0.18；P = 0.01），术后首次排气时间较短（SMD = -0.85；95%CI -1.53至-0.18；P = 0.01）。两组之间在肝功能指标（丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、总胆红素（TBiL）和国际标准化比值（INR））或术后炎症标志物（C反应蛋白（CRP）、降钙素原、白细胞介素-6（IL-6））方面未发现显著差异（所有P > 0.05）。
围手术期使用益生菌可降低肝切除患者的术后感染风险并缩短住院时间，但似乎无助于肝功能恢复或减轻炎症。
不适用。
