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Phrenic stimulation decreases brain injury biomarkers in sedated mechanically ventilated patients: preliminary observations.

作者信息

Thiago Bassi, Elizabeth Rohrs, Melodie Parfait, Brett Hannigan, Steve Reynolds, Julien Mayaux, Maxens Decavèle, Alexandre Demoule, Thomas Similowski, Martin Dres

机构信息

Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.

Lungpacer Medical Inc., Vancouver, Canada.

出版信息

Crit Care. 2025 May 26;29(1):215. doi: 10.1186/s13054-025-05435-2.

DOI:10.1186/s13054-025-05435-2
PMID:40420303
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12108019/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62f3/12108019/c041f5bd4342/13054_2025_5435_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62f3/12108019/c041f5bd4342/13054_2025_5435_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62f3/12108019/c041f5bd4342/13054_2025_5435_Fig1_HTML.jpg

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Phrenic stimulation decreases brain injury biomarkers in sedated mechanically ventilated patients: preliminary observations.膈神经刺激可降低镇静机械通气患者的脑损伤生物标志物：初步观察结果。
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2
Restoring brain connectivity by phrenic nerve stimulation in sedated and mechanically ventilated patients.在镇静和机械通气患者中通过膈神经刺激恢复脑连接性。
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本文引用的文献

1
Restoring brain connectivity by phrenic nerve stimulation in sedated and mechanically ventilated patients.在镇静和机械通气患者中通过膈神经刺激恢复脑连接性。
Commun Med (Lond). 2024 Nov 18;4(1):235. doi: 10.1038/s43856-024-00662-0.
2
Exploiting blood-based biomarkers to align preclinical models with human traumatic brain injury.利用血液中的生物标志物使临床前模型与人类创伤性脑损伤相匹配。
Brain. 2025 Apr 3;148(4):1062-1080. doi: 10.1093/brain/awae350.
3
An Initial Investigation of Diaphragm Neurostimulation in Patients with Acute Respiratory Distress Syndrome.
急性呼吸窘迫综合征患者膈神经刺激的初步研究
Anesthesiology. 2024 Mar 1;140(3):483-494. doi: 10.1097/ALN.0000000000004873.
4
Transvenous Diaphragm Neurostimulation Mitigates Ventilation-associated Brain Injury.经静脉膈肌神经刺激减轻与通气相关的脑损伤。
Am J Respir Crit Care Med. 2021 Dec 15;204(12):1391-1402. doi: 10.1164/rccm.202101-0076OC.
5
Systematic review of cognitive impairment and brain insult after mechanical ventilation.机械通气后认知障碍和脑损伤的系统评价
Crit Care. 2021 Mar 10;25(1):99. doi: 10.1186/s13054-021-03521-9.
6
Acute neuropathological consequences of short-term mechanical ventilation in wild-type and Alzheimer's disease mice.短期机械通气对野生型和阿尔茨海默病小鼠的急性神经病理学后果。
Crit Care. 2019 Feb 22;23(1):63. doi: 10.1186/s13054-019-2356-2.
7
An update on diagnostic and prognostic biomarkers for traumatic brain injury.创伤性脑损伤的诊断和预后生物标志物的最新研究进展。
Expert Rev Mol Diagn. 2018 Feb;18(2):165-180. doi: 10.1080/14737159.2018.1428089. Epub 2018 Jan 23.
8
GFAP-BDP as an acute diagnostic marker in traumatic brain injury: results from the prospective transforming research and clinical knowledge in traumatic brain injury study.胶质纤维酸性蛋白结合物 BDP 作为创伤性脑损伤的急性诊断标志物：来自前瞻性转化研究和创伤性脑损伤知识转化研究的结果。
J Neurotrauma. 2013 Sep 1;30(17):1490-7. doi: 10.1089/neu.2013.2883. Epub 2013 Aug 1.
9
Vagal nerve stimulation decreases blood-brain barrier disruption after traumatic brain injury.迷走神经刺激可减少创伤性脑损伤后血脑屏障的破坏。
J Trauma Acute Care Surg. 2012 Jun;72(6):1562-6. doi: 10.1097/TA.0b013e3182569875.
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Cortisol, interleukins and S100B in delirium in the elderly.老年谵妄中的皮质醇、白细胞介素和 S100B。
Brain Cogn. 2010 Oct;74(1):18-23. doi: 10.1016/j.bandc.2010.05.010. Epub 2010 Jun 26.