Liang Shanshan, Xu Wei, Zhong Peiying, Tao Chuanmin, Zhang Li, Jia Chengyao
Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Department of Clinical Laboratory, The Affiliated Taian City Central Hospital of Qingdao University, Taian, China.
Front Immunol. 2025 May 12;16:1565388. doi: 10.3389/fimmu.2025.1565388. eCollection 2025.
IgG4-related disease (IgG4-RD), an immune-mediated fibroinflammatory disorder, has few reports in combination with monoclonal gammopathy of undetermined significance (MGUS). Herein, we present a case of a 69-year-old woman with manifestations of left orbital occupation and visual acuity decline. Ancillary tests indicated persistent positivity of IgG4 antibody, and IgG4-RD-related ophthalmopathy was diagnosed based on the criteria. Concurrently, serum protein electrophoresis revealed an M protein level of 12.23 g/L. Immunofixation electrophoresis suggested a positive IgG λ-type M protein, and MGUS was diagnosed in conjunction with bone marrow smear and flow cytometry.
IgG4相关疾病（IgG4-RD）是一种免疫介导的纤维炎性疾病，与意义未明的单克隆丙种球蛋白病（MGUS）合并的报道较少。在此，我们报告一例69岁女性患者，有左眼眶占位和视力下降表现。辅助检查显示IgG4抗体持续阳性，根据标准诊断为IgG4-RD相关性眼病。同时，血清蛋白电泳显示M蛋白水平为12.23g/L。免疫固定电泳提示IgG λ型M蛋白阳性，结合骨髓涂片和流式细胞术诊断为MGUS。
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