Seddon John M
Chemistry Department, Molecular Sciences Research Hub, Imperial College London, Wood Lane, London W12 0BZ, UK.
Cells. 2025 May 14;14(10):716. doi: 10.3390/cells14100716.
In this review article I briefly describe lipid self-assembly, interfacial curvature, and lyotropic phase diagrams. I then go on to describe how the phase behaviour can be controlled, and the structure of lyotropic phases can be tuned, by various parameters such as temperature, hydrostatic pressure, or the addition of amphiphilic molecules such as fatty acids, diacylglycerols, and cholesterol. I then give a few illustrations of how such structures/phases may play roles in lipid-based biotechnologies, and in biomembrane systems.
在这篇综述文章中，我简要描述了脂质自组装、界面曲率和溶致相图。接着，我将阐述如何通过温度、静水压力等各种参数，或添加脂肪酸、二酰基甘油和胆固醇等两亲性分子，来控制相行为并调节溶致相的结构。然后，我将举例说明这些结构/相如何在基于脂质的生物技术以及生物膜系统中发挥作用。
