Vulciu Paula Alexandra, Pilat Luminita, Mot Maria-Daniela, Dascau Voicu, Popa Calin Daniel, Varga Norberth-Istvan, Puschita Maria
Department of Biochemistry, "Vasile Goldis" Western University, B-dul Revolutiei Nr. 96, 310025 Arad, Romania.
Department of General Medicine, "Vasile Goldis" Western University, B-dul Revolutiei Nr. 96, 310025 Arad, Romania.
Clin Pract. 2025 Apr 25;15(5):86. doi: 10.3390/clinpract15050086.
Heart failure (HF) is a leading cause of mortality across the globe, prompting ongoing research into novel biomarkers for improved risk stratification and patient management. This cross-sectional study aimed to investigate the relationship between two promising biomarkers, tetranectin and paraoxonase 1, and the severity of heart failure in a cohort of 87 patients with cardiovascular risk factors. Participants were categorized into three groups based on their New York Heart Association (NYHA) classification: no HF (Control), NYHA class I (G1), and NYHA class II-IV (G2). Our analysis revealed a stepwise decrease in both TETRA and PON1 levels with increasing HF severity, with the Control group exhibiting the highest levels and the G2 group the lowest. Interestingly, a significant positive correlation between TETRA and PON1 was observed only in the Control group, suggesting a potential interplay between these biomarkers in healthy individuals that may be disrupted with the onset of HF. Furthermore, both TETRA and PON1 were positively associated with left ventricular ejection fraction (LVEF) and negatively associated with diastolic dysfunction, indicating their potential involvement in both systolic and diastolic cardiac function. These findings suggest that TETRA and PON1 may serve as valuable biomarkers for assessing HF severity and prognosis. Further research is warranted to validate these findings in larger, prospective studies and to explore their clinical utility in guiding treatment decisions.
心力衰竭（HF）是全球范围内导致死亡的主要原因，促使人们持续开展针对新型生物标志物的研究，以改善风险分层和患者管理。这项横断面研究旨在调查两种有前景的生物标志物——四连蛋白和对氧磷酶1与87例有心血管危险因素患者队列中心力衰竭严重程度之间的关系。参与者根据纽约心脏协会（NYHA）分级分为三组：无心力衰竭（对照组）、NYHA I级（G1组）和NYHA II-IV级（G2组）。我们的分析显示，随着心力衰竭严重程度的增加，TETRA和PON1水平均呈逐步下降，对照组水平最高，G2组最低。有趣的是，仅在对照组中观察到TETRA和PON1之间存在显著正相关，这表明这些生物标志物在健康个体中可能存在潜在的相互作用，而这种相互作用可能会随着心力衰竭的发生而被破坏。此外，TETRA和PON1均与左心室射血分数（LVEF）呈正相关，与舒张功能障碍呈负相关，表明它们可能参与了心脏的收缩和舒张功能。这些发现表明，TETRA和PON1可能作为评估心力衰竭严重程度和预后的有价值的生物标志物。有必要进行进一步的研究，以在更大规模的前瞻性研究中验证这些发现，并探索它们在指导治疗决策方面的临床应用。
