通过核磁共振和质谱法鉴定正常尿液和尿毒症血浆中邻羟基苯甲酸的葡萄糖醛酸共轭物。
Identification by nuclear magnetic resonance and mass spectrometry of a glucuronic acid conjugate of o-hydroxybenzoic acid in normal urine and uremic plasma.
作者信息
Monti J P, Gallice P, Crevat A, Murisasco A
出版信息
Clin Chem. 1985 Oct;31(10):1640-3.
PMID:4042329
Abstract
An endogenous compound (included in the fraction of uremic toxins often called the "uremic middle molecules") was separated from plasma of uremic patients and urine from normal persons. As elucidated by mass spectrometry, enzymatic hydrolysis, and 1H, 13C nuclear magnetic resonance, it appears to be a conjugate of o-hydroxybenzoic acid with glucuronic acid. Its presence in urine of healthy subjects indicates its physiological character.
摘要
一种内源性化合物（包含在通常被称为“尿毒症中分子”的尿毒症毒素组分中）从尿毒症患者的血浆和正常人的尿液中分离出来。通过质谱分析、酶促水解以及1H、13C核磁共振分析表明，它似乎是邻羟基苯甲酸与葡萄糖醛酸的结合物。它在健康受试者尿液中的存在表明了其生理特性。
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