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1
Identification by nuclear magnetic resonance and mass spectrometry of a glucuronic acid conjugate of o-hydroxybenzoic acid in normal urine and uremic plasma.通过核磁共振和质谱法鉴定正常尿液和尿毒症血浆中邻羟基苯甲酸的葡萄糖醛酸共轭物。
Clin Chem. 1985 Oct;31(10):1640-3.
2
A compound from uremic plasma and from normal urine isolated by liquid chromatography and identified by nuclear magnetic resonance.一种通过液相色谱从尿毒症血浆和正常尿液中分离出来并经核磁共振鉴定的化合物。
Clin Chem. 1985 Jan;31(1):30-4.
3
Identification of two uremic toxins by nuclear magnetic resonance and mass spectrometry.通过核磁共振和质谱法鉴定两种尿毒症毒素
Adv Exp Med Biol. 1987;223:223-6. doi: 10.1007/978-1-4684-5445-1_35.
4
Ascorbic acid-2-0-beta-glucuronide, a new metabolite of vitamin C identified in human urine and uremic plasma.抗坏血酸-2-O-β-葡糖醛酸，一种在人尿液和尿毒症血浆中鉴定出的维生素C新代谢产物。
Biochim Biophys Acta. 1994 Apr 21;1199(3):305-10. doi: 10.1016/0304-4165(94)90011-6.
5
Isolation and chemical characterization of 2-hydroxybenzoylglycine as a drug binding inhibitor in uremia.尿毒症中作为药物结合抑制剂的2-羟基苯甲酰甘氨酸的分离与化学表征
J Clin Invest. 1983 May;71(5):1289-96. doi: 10.1172/jci110879.
6
A gas chromatographic-mass spectrometric assay for nine hydroxyphenolic acids in uremic serum.一种用于测定尿毒症血清中九种羟基酚酸的气相色谱 - 质谱分析法。
Clin Chim Acta. 1979 Sep 3;96(3):247-54. doi: 10.1016/0009-8981(79)90435-2.
7
Separation, identification of uremic middle molecules, and preliminary study on their toxicity.尿毒症中分子的分离、鉴定及其毒性的初步研究
Clin Chim Acta. 2004 Dec;350(1-2):89-98. doi: 10.1016/j.cccn.2004.07.003.
8
[Isolation, structure elucidation and synthesis of a hexapeptide from the hemodialysate of uremic patients].
Hoppe Seylers Z Physiol Chem. 1982 Oct;363(10):1187-202.
9
Characterization of middle molecule compounds.中分子化合物的表征
Artif Organs. 1981;4 Suppl:33-6.
10
23Na nuclear magnetic resonance study of Na+-K+ pump inhibition by a fraction from uremic toxins.利用尿毒症毒素中的一种成分对钠钾泵抑制作用的23Na核磁共振研究
Clin Chem. 1988 Oct;34(10):2044-7.

引用本文的文献

1
Characterisation of urinary metabolites of temozolomide in humans and mice and evaluation of their cytotoxicity.替莫唑胺在人和小鼠体内尿液代谢物的表征及其细胞毒性评估。
Cancer Chemother Pharmacol. 1990;26(6):429-36. doi: 10.1007/BF02994094.

通过核磁共振和质谱法鉴定正常尿液和尿毒症血浆中邻羟基苯甲酸的葡萄糖醛酸共轭物。

Identification by nuclear magnetic resonance and mass spectrometry of a glucuronic acid conjugate of o-hydroxybenzoic acid in normal urine and uremic plasma.

作者信息

Monti J P, Gallice P, Crevat A, Murisasco A

出版信息

Clin Chem. 1985 Oct;31(10):1640-3.

PMID:4042329
Abstract

An endogenous compound (included in the fraction of uremic toxins often called the "uremic middle molecules") was separated from plasma of uremic patients and urine from normal persons. As elucidated by mass spectrometry, enzymatic hydrolysis, and 1H, 13C nuclear magnetic resonance, it appears to be a conjugate of o-hydroxybenzoic acid with glucuronic acid. Its presence in urine of healthy subjects indicates its physiological character.

摘要

一种内源性化合物（包含在通常被称为“尿毒症中分子”的尿毒症毒素组分中）从尿毒症患者的血浆和正常人的尿液中分离出来。通过质谱分析、酶促水解以及1H、13C核磁共振分析表明，它似乎是邻羟基苯甲酸与葡萄糖醛酸的结合物。它在健康受试者尿液中的存在表明了其生理特性。