Ma Rui, Wu Zidong, Guo Xiaoyu, Wu Zixuan, Zhu Zheyue, Qu Yuning, Wang Kunzheng, Li Chengxin, Ma Kai, Yang Pei
Joint and Foot & Ankle Ward of Orthopedic Center, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shanxi, China.
State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, Xi'an Jiaotong University, Xi'an 710049, China.
J Mater Chem B. 2025 Jun 18;13(24):7155-7171. doi: 10.1039/d5tb00628g.
Polyetheretherketone (PEEK) is a promising orthopedic implant alternative to metals due to its bone-mimetic modulus and biocompatibility; yet, its bioinert nature often triggers fibrous encapsulation and impedes osteointegration. Here, a biodegradable calcium silicate/β-tricalcium phosphate (CS/TCP) composite coating was fabricated on sulfonated PEEK (SP) vacuum cold spraying to address these limitations. The CS/TCP coating exhibited robust bonding strength, enhanced hydrophilicity, and sustained release of Ca/Si ions, fostering apatite deposition in simulated body fluid. This bioactive interface promoted an immunomodulatory microenvironment by polarizing macrophages toward the anti-inflammatory M2 phenotype. Synergistically, ionic release and cytokine secretion enhanced MC3T3-E1 cell adhesion, proliferation, and osteogenic differentiation. , CS/TCP-SP reduced fibrous tissue thickness in a rat air-pouch model and improved bone-implant integration in rabbit cranial defects. The scalable coating strategy transforms inert PEEK into a bioactive, immunoregulatory implant, demonstrating potential to mitigate aseptic loosening and revision surgeries.
聚醚醚酮（PEEK）因其类骨模量和生物相容性，是一种很有前景的替代金属的骨科植入物；然而，其生物惰性往往会引发纤维包裹并阻碍骨整合。在此，通过真空冷喷涂在磺化聚醚醚酮（SP）上制备了一种可生物降解的硅酸钙/β-磷酸三钙（CS/TCP）复合涂层，以解决这些局限性。CS/TCP涂层表现出强大的结合强度、增强的亲水性以及钙/硅离子的持续释放，促进了模拟体液中磷灰石的沉积。这种生物活性界面通过将巨噬细胞极化为抗炎M2表型，促进了免疫调节微环境。协同作用下，离子释放和细胞因子分泌增强了MC3T3-E1细胞的粘附、增殖和成骨分化。在大鼠气袋模型中，CS/TCP-SP降低了纤维组织厚度，并改善了兔颅骨缺损中的骨植入物整合。这种可扩展的涂层策略将惰性PEEK转变为具有生物活性、免疫调节功能的植入物，显示出减轻无菌性松动和翻修手术的潜力。
