新型冷冻肾去神经支配系统的临床前评估

Preclinical Evaluation of a Novel Cryo Renal Denervation System.

作者信息

Krackhardt Florian, Tsioufis Konstantinos, Lauder Lucas, Drude Natascha, Adaway Jo, Keevil Brian, Klemm Holger, Haider Wolfram, Beele Alicia, Wild Léa, Joner Michael, Mahfoud Felix

机构信息

Deutsches Herzzentrum der Charité Universitätsmedizin Berlin, Klinik mit Schwerpunkt Kardiologie, Angiologie und Intensivmedizin, Berlin, Germany.

First Cardiology Department, School of Medicine, "Hippokration" General Hospital, National and Kapodistrian University of Athens, Athens, Greece.

出版信息

JACC Basic Transl Sci. 2025 Feb 21;10(6):745-54. doi: 10.1016/j.jacbts.2025.01.014.

The objective of this study was to demonstrate the safety and efficacy of a novel cryo renal denervation system (Cryo-RDN) in a porcine model. Procedural and mid-term safety of the Cryo-RDN was demonstrated. Efficacy of the cryoablation was evidenced by histological findings in the renal arteries and reduced renal tissue norepinephrine concentrations on the treated sides. Despite some morphological nerve repair observed between 7 and 28 days, the greater renal norepinephrine suppression in the 28-day animals suggests irreversibly ablated sympathetic nerves.