Krackhardt Florian, Tsioufis Konstantinos, Lauder Lucas, Drude Natascha, Adaway Jo, Keevil Brian, Klemm Holger, Haider Wolfram, Beele Alicia, Wild Léa, Joner Michael, Mahfoud Felix
Deutsches Herzzentrum der Charité Universitätsmedizin Berlin, Klinik mit Schwerpunkt Kardiologie, Angiologie und Intensivmedizin, Berlin, Germany.
First Cardiology Department, School of Medicine, "Hippokration" General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
JACC Basic Transl Sci. 2025 Feb 21;10(6):745-54. doi: 10.1016/j.jacbts.2025.01.014.
The objective of this study was to demonstrate the safety and efficacy of a novel cryo renal denervation system (Cryo-RDN) in a porcine model. Procedural and mid-term safety of the Cryo-RDN was demonstrated. Efficacy of the cryoablation was evidenced by histological findings in the renal arteries and reduced renal tissue norepinephrine concentrations on the treated sides. Despite some morphological nerve repair observed between 7 and 28 days, the greater renal norepinephrine suppression in the 28-day animals suggests irreversibly ablated sympathetic nerves.
本研究的目的是在猪模型中证明一种新型冷冻肾去神经支配系统（Cryo-RDN）的安全性和有效性。证明了Cryo-RDN的操作安全性和中期安全性。肾动脉的组织学发现以及治疗侧肾组织去甲肾上腺素浓度降低证明了冷冻消融的有效性。尽管在7至28天之间观察到一些神经形态修复，但28天龄动物中更大程度的肾去甲肾上腺素抑制表明交感神经已被不可逆地消融。
