成功的肿瘤免疫疗法：针对肿瘤产生的抗炎因子的抗体的可能作用。
Successful tumour immunotherapy: possible role of antibodies to anti-inflammatory factors produced by neoplasms.
作者信息
Nelson M, Nelson D S, Spradbrow P B, Kuchroo V K, Jennings P A, Cianciolo G J, Snyderman R
出版信息
Clin Exp Immunol. 1985 Jul;61(1):109-17.
Abstract
Phenol-saline tumour extracts, active in the immunotherapy of bovine ocular squamous cell carcinoma (BOSCC), were used to immunize mice. The immunized mice became resistant to the depression of delayed type hypersensitivity (DTH) reactions by products of BOSCC cells or cultured mouse or rat tumour cells. They also showed partial resistance to the growth of an unrelated tumour. Monoclonal antibodies to a type C retrovirus protein, p15E, also induced resistance to the depression of DTH by products of BOSCC and mouse tumours. It is suggested that successful immunotherapy of BOSCC is associated with the induction of resistance to anti-inflammatory or immunosuppressive tumour cell products, allowing the operation of host defences, and that these products share antigenic determinants with a retrovirus protein.
摘要
在牛眼鳞状细胞癌（BOSCC）免疫治疗中具有活性的苯酚 - 盐水肿瘤提取物被用于免疫小鼠。免疫后的小鼠对BOSCC细胞产物或培养的小鼠或大鼠肿瘤细胞产物所导致的迟发型超敏反应（DTH）抑制具有抗性。它们还对无关肿瘤的生长表现出部分抗性。针对C型逆转录病毒蛋白p15E的单克隆抗体也诱导了对BOSCC和小鼠肿瘤产物所致DTH抑制的抗性。有人提出，BOSCC的成功免疫治疗与诱导对抗炎或免疫抑制肿瘤细胞产物的抗性相关，从而使宿主防御机制得以发挥作用，并且这些产物与一种逆转录病毒蛋白具有共同的抗原决定簇。
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本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Monocyte responsiveness to chemotactic stimuli is a property of a subpopulation of cells that can respond to multiple chemoattractants.单核细胞对趋化刺激的反应性是一类能够对多种趋化因子作出反应的细胞亚群所具有的特性。
J Clin Invest. 1981 Jan;67(1):60-8. doi: 10.1172/JCI110033.
3
Immunotherapy of bovine ocular squamous cell carcinomas with phenol-saline extracts of allogenic carcinomas.用同种异体癌的酚盐水提取物对牛眼鳞状细胞癌进行免疫治疗。
Aust Vet J. 1981 Apr;57(4):159-62. doi: 10.1111/j.1751-0813.1981.tb00502.x.
4
Macrophages and resistance of tumors 6. The effects of supernatants from cultures of normal and tumor cells on phagocytosis.巨噬细胞与肿瘤抗性6. 正常细胞和肿瘤细胞培养上清液对吞噬作用的影响。
J Reticuloendothel Soc. 1982 May;31(5):433-50.
5
Inhibition of cytokine production by a tumor cell product.肿瘤细胞产物对细胞因子产生的抑制作用。
Immunology. 1982 Jul;46(3):603-12.
6
Inhibitors of monocyte responses to chemotaxins are present in human cancerous effusions and react with monoclonal antibodies to the P15(E) structural protein of retroviruses.人类癌性积液中存在单核细胞对趋化因子反应的抑制剂，且这些抑制剂能与抗逆转录病毒P15（E）结构蛋白的单克隆抗体发生反应。
J Clin Invest. 1981 Oct;68(4):831-44. doi: 10.1172/jci110338.
7
Efficacy of intratumorally administered mycobacterial cell walls in the treatment of cattle with ocular carcinoma.瘤内注射分枝杆菌细胞壁治疗牛眼癌的疗效
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Macrophages and resistance to tumors. IV. Influence of age on susceptibility of mice to anti-inflammatory and antimacrophage effects of tumor cell products.巨噬细胞与肿瘤抗性。IV. 年龄对小鼠易受肿瘤细胞产物抗炎及抗巨噬细胞效应影响的作用。
J Natl Cancer Inst. 1980 Oct;65(4):781-9. doi: 10.1093/jnci/65.4.781.
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Human malignant and mitogen-transformed cells contain retroviral P15E-related antigen.人类恶性细胞和有丝分裂原转化细胞含有逆转录病毒P15E相关抗原。
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