Koopman M G, Krediet R T, Zuyderhoudt F J, De Moor E A, Arisz L
Clin Sci (Lond). 1985 Oct;69(4):395-401. doi: 10.1042/cs0690395.
Circadian variations in proteinuria were studied in 17 patients with different types of glomerulopathies. During 3-4 successive days urine was collected over periods of 3 h under standardized conditions. Thirteen of the 17 patients showed a circadian rhythm of their proteinuria with a maximum excretion in daytime around 16.00 hours and a minimum excretion at night around 03.00 hours. In the majority of patients the urinary excretory rhythms of albumin, transferrin and immunoglobulin G were 'in phase' with each other and with the circadian rhythm of total protein excretion. Nine patients had a larger degree of rhythmicity for immunoglobulin G than for transferrin excretion. In eight of them a circadian rhythm of the selectivity index of proteinuria was seen with the lowest index at night. No relation was observed between the circadian rhythm of proteinuria and the type of glomerulopathy.
对17例不同类型肾小球病患者的蛋白尿昼夜变化进行了研究。在连续3 - 4天里，在标准化条件下每隔3小时收集一次尿液。17例患者中有13例蛋白尿呈现昼夜节律，白天约16:00时排泄量最高，夜间约03:00时排泄量最低。大多数患者中，白蛋白、转铁蛋白和免疫球蛋白G的尿排泄节律彼此“同步”，且与总蛋白排泄的昼夜节律同步。9例患者免疫球蛋白G的节律性程度大于转铁蛋白排泄的节律性程度。其中8例患者蛋白尿选择性指数呈现昼夜节律，夜间指数最低。未观察到蛋白尿昼夜节律与肾小球病类型之间的关联。
