Rangasamy Savitha, Rao Arun
Department of Obstetrics and Gynecology, Kasturba Medical College (Manipal Academy of Higher Education), Mangalore, India ; Prabhu Polyclinic, 95, New Scheme Road, Pollachi, 642002 Tamil Nadu India.
J Obstet Gynaecol India. 2012 Aug;62(4):424-8. doi: 10.1007/s13224-012-0299-5. Epub 2012 Oct 16.
To evaluate whether the gold standard of 24-h urinary albumin excretion in preeclamptic women could be substituted by a shorter collection period.
From each woman, three spot, two 12-h, and one 24-h urine samples were collected. For each sample, urine albumin concentrations in milligram per liter were analyzed by the immunoturbidimetric method. The albumin concentrations in the spot and 12-h collections (day and night) were compared with the 24-h urine collection.
Albumin concentrations in both 12-h collections were fitted closely with the concentrations of the 24-h collection. The median difference between the 24-h collection and the day collection was 43 mg/L and the correlation coefficient was 0.96 (p < 0.0001). The median difference between the night collection and the 24-h collection was -31 mg/L and the correlation coefficient was 0.98 (p < 0.0001).
The gold standard of 24-h urinary albumin concentrations in preeclamptic women can be substituted with a 12-h collection. Spot samples were weaker as compared to the 12-h collection.
评估子痫前期女性24小时尿白蛋白排泄的金标准是否可以用更短的收集时间段替代。
收集每位女性的三份随机尿样、两份12小时尿样和一份24小时尿样。对每份样本，采用免疫比浊法分析每升尿样中白蛋白的浓度（毫克）。将随机尿样和12小时尿样（白天和夜间）中的白蛋白浓度与24小时尿样中的进行比较。
两份12小时尿样中的白蛋白浓度与24小时尿样中的浓度拟合度很高。24小时尿样与白天尿样之间的中位数差异为43毫克/升，相关系数为0.96（p<0.0001）。夜间尿样与24小时尿样之间的中位数差异为-31毫克/升，相关系数为0.98（p<0.0001）。
子痫前期女性24小时尿白蛋白浓度的金标准可用12小时尿样替代。与12小时尿样相比，随机尿样的相关性较差。
