Fang Yan, Wang Linyu, Zheng Xinwei, Ni Peng, Xu Zhibo, Wang Ziying, Weng Yunxiang, Chen Qinhui, Liu Haiqing
College of Chemistry and Materials Science, Fujian Key Laboratory of Polymer Materials, Fujian Normal University, Fujian, China.
Nat Commun. 2025 May 27;16(1):4910. doi: 10.1038/s41467-025-60244-z.
Current hemostatic fabric often encounters the issue of blood seeping or leaking through the fabric and at the junctions between the fabric and tissue, leading to extra blood loss. Herein, we report a hemostatic nanofabric composed of anionic and cationic nanofibers. Upon contact with wound, the porous nanofabric can absorb the interfacial blood and self-seal to form a compact physical barrier through interfiber bonding, preventing blood from longitudinally penetrating the fabric. This process results in the encapsulation of blood components within the electrostatically crosslinked nanofiber network, creating a robust thrombus that reinforces the physical barrier. Moreover, this nanofabric exhibits strong tissue adhesiveness, inhibiting blood seeping out at the seam of the fabric and tissue. Its hemostatic performance in animal injuries surpasses that of standard cotton gauze and Combat Gauze. In the pig femoral artery injury, the blood loss from the nanofabric is only ca. 8% of that from Combat Gauze. The nanofabric exhibits excellent biodegradability, hemocompatibility, cytocompatibility, antibacterial activity, and wound healing promotion.
目前的止血织物常常面临血液从织物及其与组织的连接处渗出或渗漏的问题，导致额外的失血。在此，我们报道了一种由阴离子和阳离子纳米纤维组成的止血纳米织物。与伤口接触时，这种多孔纳米织物能够吸收界面血液并通过纤维间结合实现自密封，形成紧密的物理屏障，防止血液纵向穿透织物。这一过程导致血液成分被包裹在静电交联的纳米纤维网络中，形成一个坚固的血栓，加强了物理屏障。此外，这种纳米织物表现出很强的组织粘附性，可抑制血液从织物与组织的接缝处渗出。其在动物损伤中的止血性能超过了标准棉纱和战斗纱布。在猪股动脉损伤中，纳米织物的失血量仅约为战斗纱布的8%。该纳米织物具有优异的生物降解性、血液相容性、细胞相容性、抗菌活性以及促进伤口愈合的能力。
