Natsuume-Sakai S, Motonishi K, Takahashi M
Int Arch Allergy Appl Immunol. 1977;53(3):269-78. doi: 10.1159/000231762.
The effect of age, sex, genetic backgrounds and environmental factors on mouse C3 level was studied. In general, C3 level increased as a mouse became older. Little difference in C3 level was observed between male and female of all ages. C3 level was found in a great variation from strain to strain, but we could not demonstrate any major role of H-2 in determining serum C3 level. Serum C3 level is not shown to be linked to the serum level of H-2 linked serum protein Ss (C4). On the other hand a close correlation between C3 level and C5 level was demonstrated. Serum C3 markedly increased, along with C5, when mice were injected with turpentine oil, suggesting both components are acute phase reactants. The degree of increase in C3 level in response to turpentine oil injection appeared to be controlled by a single or a very few genes probably not linked to H-2.
研究了年龄、性别、遗传背景和环境因素对小鼠C3水平的影响。一般来说，随着小鼠年龄的增长，C3水平会升高。在所有年龄段的雄性和雌性小鼠之间，未观察到C3水平有显著差异。不同品系小鼠的C3水平差异很大，但我们无法证明H-2在决定血清C3水平方面有任何主要作用。血清C3水平未显示与H-2连锁血清蛋白Ss（C4）的血清水平相关。另一方面，已证明C3水平与C5水平密切相关。当给小鼠注射松节油时，血清C3与C5一起显著升高，这表明这两种成分都是急性期反应物。注射松节油后C3水平的升高程度似乎受一个或极少数可能与H-2不连锁的基因控制。
