ALK 阳性间变性大细胞淋巴瘤中的循环肿瘤 DNA：一项概念验证研究。
Circulating tumor DNA in ALK-positive anaplastic large cell lymphoma: a proof-of-concept study.
作者信息
Vasseur Damien, Abbou Samuel, Lacroix Ludovic, Lamant Laurence, Pata-Merci Noémie, Sibon David, Facchinetti Francesco, Deloger Marc, Braye Floriane, Minard-Colin Véronique, Brugières Laurence, Rouleau Etienne, Friboulet Luc, Rigaud Charlotte
机构信息
Medical Biology and Pathology Department, Villejuif, France.
AMMICa UAR3655/US23, Villejuif, France.
出版信息
NPJ Precis Oncol. 2025 May 27;9(1):157. doi: 10.1038/s41698-025-00944-3.
In this multicenter study, we were able to detect circulating tumor DNA (ctDNA) in 87.5% of patients with the rare disease ALK + ALCL. Moreover, by analyzing ctDNA from samples collected at disease progression, we were able to identify resistance mutations to ALK inhibitors. Furthermore, ctDNA proved to be a valuable and consistent tool for monitoring minimal residual disease.
在这项多中心研究中，我们能够在87.5%的罕见病ALK+间变性大细胞淋巴瘤（ALCL）患者中检测到循环肿瘤DNA（ctDNA）。此外，通过分析疾病进展时采集样本中的ctDNA，我们能够识别出对ALK抑制剂的耐药突变。此外，ctDNA被证明是监测微小残留病的一种有价值且可靠的工具。
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