Lu Li, Xu Zheng, Miao Zeyang, Zuo Xiaoyong, Shi Dan, Chang Shixin, Luo Peng, Li Guanwu
Department of Radiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 110 Ganhe Rd, Shanghai, 200437, China.
Changshou Community Health Center, Shanghai, China.
J Bone Miner Metab. 2025 May 27. doi: 10.1007/s00774-025-01609-8.
The systemic immune-inflammation index (SII) may influence bone homeostasis through inflammatory modulation. Although bone marrow adipocytes regulate bone metabolism via adipokine secretion, their interaction with SII remains unexplored. We investigated the SII-marrow adiposity relationship in postmenopausal women.
This retrospective study included 187 postmenopausal women. Lumbar spine MRI using chemical shift encoding generated proton density fat fraction (PDFF) maps, with bone mineral density (BMD) measured by dual x-ray absorptiometry. The relationship between SII and marrow PDFF was evaluated through multivariable-adjusted linear regression, smooth curve fittings, and threshold analysis.
The results revealed a negative correlation between marrow PDFF values and BMD (r = - 0.438, P < 0.001). After accounting for age, time since menopause, body mass index, physical activity, C-reactive protein, interleukin (IL)-1β, IL-6, tumor necrosis factor-α, and BMD in the regression analysis, each unit increase in SII was found to be inked to an increase of 0.247 (β = 0.247; 95% confidence interval [CI], 0.212 to 0.281; P <0.001) in PDFF. After converting SII to a categorical variable (quartiles), participants in the highest SII quartile had a 16.8% higher vertebral marrow PDFF than those in the lowest SII quartile (β = 16.753, 95% CI: 11.036-18.522, P <0.001). Furthermore, a curvilinear relationship and threshold effect were also identified. Turning point was identified at the SII value of 441 on the adjusted smooth curve.
SII levels were positively associated with marrow adiposity in postmenopausal women.
全身免疫炎症指数（SII）可能通过炎症调节影响骨稳态。尽管骨髓脂肪细胞通过分泌脂肪因子调节骨代谢，但其与SII的相互作用仍未得到探索。我们研究了绝经后女性中SII与骨髓脂肪的关系。
这项回顾性研究纳入了187名绝经后女性。使用化学位移编码的腰椎MRI生成质子密度脂肪分数（PDFF）图，并通过双能X线吸收法测量骨密度（BMD）。通过多变量调整线性回归、平滑曲线拟合和阈值分析评估SII与骨髓PDFF之间的关系。
结果显示骨髓PDFF值与BMD之间呈负相关（r = -0.438，P <0.001）。在回归分析中考虑年龄、绝经时间、体重指数、身体活动、C反应蛋白、白细胞介素（IL）-1β、IL-6、肿瘤坏死因子-α和BMD后，发现SII每增加一个单位，PDFF增加0.247（β = 0.247；95%置信区间[CI]，0.212至0.281；P <0.001）。将SII转换为分类变量（四分位数）后，SII最高四分位数的参与者的椎体骨髓PDFF比SII最低四分位数的参与者高16.8%（β = 16.753，95% CI：11.036 - 18.522，P <0.001）。此外，还确定了曲线关系和阈值效应。在调整后的平滑曲线上，转折点的SII值为441。
绝经后女性的SII水平与骨髓脂肪呈正相关。
