Department of Orthopedics, Suzhou BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Suzhou, China.
Department of Orthopedics, Suzhou Industrial Park Xinghu Hospital, Suzhou, China.
Immun Inflamm Dis. 2024 Aug;12(8):e1365. doi: 10.1002/iid3.1365.
This study aims to investigate the correlation between changes in bone mineral density (BMD) in postmenopausal women and circulating inflammatory markers.
This retrospective study focused on postmenopausal women admitted to the orthopedic department of Suzhou Benq Medical Center from June 2022 to December 2023, following predetermined inclusion and exclusion criteria. We retrospectively collected data on initial blood routine test results and bone density measurements for all study subjects upon admission, including parameters such as white blood cell count (WBC), C-reactive protein, interleukin-6 (IL-6), and procalcitonin (PCT). Additionally, the systemic immune-inflammation index (SII) was calculated using neutrophil count, lymphocyte count, and platelet count. Statistical analyses using SPSS and GraphPad software were performed to assess the correlation between bone density and inflammatory markers.
Patients were classified into three groups based on BMD results, including 60 individuals in the osteoporosis (OP) group, 127 individuals in the osteopenia group, and 37 individuals in the Normal group, respectively. Principal component analysis analysis suggested that WBC, SII, and postmenopausal OP (PMOP) held significant feature values. Correlation analysis indicated a correlation between WBC (p = 0.021), IL-6 (p = 0.044), SII (p = 0.034), and PMOP. One-way ANOVA analysis revealed significant differences in IL-6 (p = 0.0179), SII (p = 0.0210), and PCT (p = 0.0200) among the three groups. Finally, ROC curve analysis demonstrated that SII (area under the curve = 0.716) has predictive value for PMOP.
This study identified a certain predictive value for PMOP through the assessment of inflammatory markers in peripheral blood using routine blood tests.
本研究旨在探讨绝经后妇女骨密度（BMD）变化与循环炎症标志物之间的相关性。
本回顾性研究聚焦于 2022 年 6 月至 2023 年 12 月期间在苏州本富医疗中心骨科就诊的绝经后妇女，符合既定的纳入和排除标准。我们回顾性地收集了所有研究对象入院时的初始血常规检查结果和骨密度测量数据，包括白细胞计数（WBC）、C 反应蛋白、白细胞介素-6（IL-6）和降钙素原（PCT）等参数。此外，还使用中性粒细胞计数、淋巴细胞计数和血小板计数计算了全身免疫炎症指数（SII）。使用 SPSS 和 GraphPad 软件进行统计分析，以评估骨密度与炎症标志物之间的相关性。
根据 BMD 结果，患者被分为三组，骨质疏松（OP）组 60 例，骨质减少（OP）组 127 例，正常组 37 例。主成分分析提示白细胞计数（WBC）、SII 和绝经后骨质疏松症（PMOP）具有显著特征值。相关性分析表明，白细胞计数（p=0.021）、白细胞介素-6（p=0.044）、SII（p=0.034）与 PMOP 之间存在相关性。单因素方差分析显示三组间白细胞介素-6（p=0.0179）、SII（p=0.0210）和 PCT（p=0.0200）有显著差异。最后，ROC 曲线分析表明 SII（曲线下面积=0.716）对 PMOP 具有预测价值。
本研究通过对常规血常规检查外周血中的炎症标志物进行评估，发现了对 PMOP 有一定的预测价值。
