Camacho-González Carlos E, Cardona-Felix Cesar S, Pérez-Larios Alejandro, Zamora-Gasga Víctor M, Sáyago-Ayerdi Sonia G, Sánchez-Burgos Jorge A
Food Research Laboratory, Technological Institute of Tepic, National Technological Institute of Mexico, Instituto Tecnológico Avenue No. 2595, Lagos del Country, Tepic C.P. 63175, Nayarit, Mexico.
Instituto Politécnico Nacional, CICIMAR, Av. Instituto Politécnico Nacional S/N, Col. Playa Palo de Santa Rita, La Paz C.P. 23096, Baja California, Mexico.
Antibiotics (Basel). 2025 Apr 30;14(5):457. doi: 10.3390/antibiotics14050457.
The growing threat of multidrug-resistant bacteria requires innovative therapies beyond traditional antibiotics. This review highlights the potential of endolysin biocomposites using alginate oligosaccharides (AOSs) and modified cellulose (CL) as stabilizers. AOSs could enhance endolysin stability and potentially support colonic fermentation, producing short-chain fatty acids that may synergize with endolysins to combat pathogens and improve gut health. KZ144 and LysPA26 are proposed as optimal candidates for their broad pH range, divalent cation tolerance, and potential effectiveness against Gram-positive and Gram-negative pathogens. Integrating AOSs and CL into biocomposites could offer a novel dual-action strategy against gastrointestinal diseases while potentially reducing antibiotic dependence.
多重耐药细菌日益增长的威胁需要超越传统抗生素的创新疗法。本综述强调了使用海藻寡糖（AOSs）和改性纤维素（CL）作为稳定剂的溶菌酶生物复合材料的潜力。AOSs可以增强溶菌酶的稳定性，并有可能支持结肠发酵，产生短链脂肪酸，这些短链脂肪酸可能与溶菌酶协同作用以对抗病原体并改善肠道健康。KZ144和LysPA26因其宽泛的pH范围、二价阳离子耐受性以及对革兰氏阳性和革兰氏阴性病原体的潜在有效性而被提议作为最佳候选物。将AOSs和CL整合到生物复合材料中可以提供一种针对胃肠道疾病的新型双重作用策略，同时有可能减少对抗生素的依赖。
