Veveloyiannis Panayiotis, Bafaloukas Nikolaos, Mouliou Dimitra S
Minimal Invasive Urology Clinic MITERA Hospital HHG Group, 15123 Marousi, Greece.
Forth Urological Department, IASO Hospital, 15123 Marousi, Greece.
Cancers (Basel). 2025 May 10;17(10):1608. doi: 10.3390/cancers17101608.
Holmium Laser Enucleation of the Prostate (HoLEP) is an established treatment for benign prostatic hyperplasia (BPH). Pulse-modulated lasers, like MOSES technology (MoLEP), may enhance the procedure's efficiency and safety.
A 3-year single-center retrospective comparative study was conducted on 1368 patients treated with HoLEP/MoLEP at MITERA Hospital.
A total of 688 patients were treated with HoLEP and 680 with MoLEP. Compared to HoLEP, MoLEP demonstrated shorter surgical (50.5 min [IQR 33-60] vs. 58 min [IQR 46-69], < 0.01) and enucleation times (34 min [IQR 23-43] vs. 43 min [IQR 34-51], < 0.001) and shorter hospital stay (8 h [IQR 6-19] vs. 12 h [IQR 9-24], = 0.027), catheterization time (19 h [IQR 12-48] vs. 24 h [IQR 24-48], < 0.001), and irrigation duration (5 h [IQR 2-8] vs. 7 h [IQR 3-10], < 0.001), with similar morcellated tissue weight and morcellation time. At 1 month, MoLEP showed higher Qmax (27.3 mL/s [IQR 23.9-30.3] vs. 20 mL/s [IQR 17-23.6], < 0.001), lower PVR (11.4 mL [IQR 7.7-15] vs. 12.5 mL [IQR 7-18], = 0.005), better IPSS (4 [IQR 3-6] vs. 7 [IQR 5-11], < 0.005), QoL (1 [IQR 1-2] vs. 2 [IQR 1-2], < 0.001), lower PSA (1.8 ng/mL [IQR 1.1-2.6] vs. 2.4 ng/mL [IQR 1.3-3.5], < 0.001), which were maintained at 6 months, and fewer Clavien-Dindo I (2.5% vs. 7.5%, < 0.001) and II (16% vs. 25.7%, < 0.001) complications.
MoLEP offered significant advantages over HoLEP in this study.
钬激光前列腺剜除术（HoLEP）是治疗良性前列腺增生（BPH）的一种成熟方法。脉冲调制激光，如MOSES技术（MoLEP），可能会提高该手术的效率和安全性。
对在米特拉医院接受HoLEP/MoLEP治疗的1368例患者进行了一项为期3年的单中心回顾性比较研究。
共有688例患者接受了HoLEP治疗，680例接受了MoLEP治疗。与HoLEP相比，MoLEP的手术时间（50.5分钟[四分位间距33 - 60] vs. 58分钟[四分位间距46 - 69]，P < 0.01）和剜除时间（34分钟[四分位间距23 - 43] vs. 43分钟[四分位间距34 - 51]，P < 0.001）更短，住院时间（8小时[四分位间距6 - 19] vs. 12小时[四分位间距9 - 24]，P = 0.027）、导尿时间（19小时[四分位间距12 - 48] vs. 24小时[四分位间距24 - 48]，P < 0.001）和冲洗持续时间（5小时[四分位间距2 - 8] vs. 7小时[四分位间距3 - 10]，P < 0.001）也更短，碎组织重量和碎除时间相似。在1个月时，MoLEP的最大尿流率更高（27.3毫升/秒[四分位间距23.9 - 30.3] vs. 20毫升/秒[四分位间距17 - 23.6]，P < 0.001），残余尿量更低（11.4毫升[四分位间距7.7 - 15] vs. 12.5毫升[四分位间距7 - 18]，P = 0.005），国际前列腺症状评分（IPSS）更好（4[四分位间距3 - 6] vs. 7[四分位间距5 - 11]，P < 0.005），生活质量（QoL）更高（1[四分位间距1 - 2] vs. 2[四分位间距1 - 2]，P < 0.001），前列腺特异性抗原（PSA）更低（1.8纳克/毫升[四分位间距1.1 - 2.6] vs. 2.4纳克/毫升[四分位间距1.3 - 3.5]，P < 0.001），这些指标在术后6个月时仍保持，且Clavien-Dindo I级（2.5% vs. 7.5%，P < 0.
